Technology Process of 6-fluoro-3-(4-methoxyphenyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline
There total 6 articles about 6-fluoro-3-(4-methoxyphenyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trifluoride diethyl etherate;
In
1,2-dichloro-ethane;
at 80 ℃;
for 6h;
Molecular sieve;
Inert atmosphere;
DOI:10.1021/jo300635m
- Guidance literature:
-
Multi-step reaction with 5 steps
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine
2: palladium 10% on activated carbon; hydrogen / ethanol
3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
4: manganese(IV) oxide / dichloromethane
5: boron trifluoride diethyl etherate / 1,2-dichloro-ethane / 6 h / 80 °C / Molecular sieve; Inert atmosphere
With
manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium aluminium tetrahydride; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane;
1: Sonogashira coupling;
DOI:10.1021/jo300635m
- Guidance literature:
-
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / ethanol
2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
3: manganese(IV) oxide / dichloromethane
4: boron trifluoride diethyl etherate / 1,2-dichloro-ethane / 6 h / 80 °C / Molecular sieve; Inert atmosphere
With
manganese(IV) oxide; lithium aluminium tetrahydride; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen;
In
tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo300635m
