1-(7-(benzyloxy)-4,5-difluorospiro[indoline-3,4'-piperidine]-1'-yl)-2,2-dimethylpropan-1-one

Base Information

Chemical Name:1-(7-(benzyloxy)-4,5-difluorospiro[indoline-3,4'-piperidine]-1'-yl)-2,2-dimethylpropan-1-one
CAS No.:1557207-84-7
Molecular Formula:C₂₄H₂₈F₂N₂O₂
Molecular Weight:414.495
Hs Code.:

Synonyms:1-(7-(benzyloxy)-4,5-difluorospiro[indoline-3,4'-piperidine]-1'-yl)-2,2-dimethylpropan-1-one

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Chemical Property of 1-(7-(benzyloxy)-4,5-difluorospiro[indoline-3,4'-piperidine]-1'-yl)-2,2-dimethylpropan-1-one

Chemical Property:

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Technology Process of 1-(7-(benzyloxy)-4,5-difluorospiro[indoline-3,4'-piperidine]-1'-yl)-2,2-dimethylpropan-1-one

There total 7 articles about 1-(7-(benzyloxy)-4,5-difluorospiro[indoline-3,4'-piperidine]-1'-yl)-2,2-dimethylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₉F₂N₃O₂

: 1557207-84-7
1-(7-(benzyloxy)-4,5-difluorospiro[indoline-3,4'-piperidine]-1'-yl)-2,2-dimethylpropan-1-one

Guidance literature:: C₂₄H₂₉F₂N₃O₂; With sulfuric acid; In ethanol; at 20 ℃; for 16h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; ethanol; at -10 ℃;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1557207-84-7
1-(7-(benzyloxy)-4,5-difluorospiro[indoline-3,4'-piperidine]-1'-yl)-2,2-dimethylpropan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,2-dichloro-ethane / 4 h / 23 °C

2.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: ethanol / 1 h / 20 °C / Inert atmosphere

4.1: sulfuric acid / ethanol / 16 h / 20 °C / Inert atmosphere

4.2: -10 °C

With sulfuric acid; Dess-Martin periodane; triethylamine; In ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 155535-54-9
1-(4-(hydroxymethyl)piperidin-1-yl)-2,2-dimethylpropan-1-one

: 1557207-84-7
1-(7-(benzyloxy)-4,5-difluorospiro[indoline-3,4'-piperidine]-1'-yl)-2,2-dimethylpropan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: ethanol / 1 h / 20 °C / Inert atmosphere

3.1: sulfuric acid / ethanol / 16 h / 20 °C / Inert atmosphere

3.2: -10 °C

With sulfuric acid; Dess-Martin periodane; In ethanol; dichloromethane;