[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-feri-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyrazin-2-yl-methanone

Base Information

Chemical Name:[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-feri-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyrazin-2-yl-methanone
CAS No.:1402048-16-1
Molecular Formula:C₃₉H₅₅N₃O₃S₂
Molecular Weight:678.016
Hs Code.:

Synonyms:[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-feri-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyrazin-2-yl-methanone

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Chemical Property of [4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-feri-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyrazin-2-yl-methanone

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Technology Process of [4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-feri-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyrazin-2-yl-methanone

There total 5 articles about [4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-feri-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyrazin-2-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 98-97-5
2-pyrazylcarboxylic acid

: 1402048-10-5
2,6-di-tert-butyl-4-[4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-4-ylsulfanyl]-phenol

: 1402048-16-1
[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-feri-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyrazin-2-yl-methanone

Guidance literature:: 2-pyrazylcarboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 18h;

2,6-di-tert-butyl-4-[4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-4-ylsulfanyl]-phenol; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 6h;

Reference yield:

: 950-59-4
4-hydroxy-3,5-di-tert-butylthiophenol

: 1402048-16-1
[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-feri-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyrazin-2-yl-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol / 20 h / 45 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

3.2: 20 °C / pH ~ 6

4.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

4.2: 6 h / 20 °C

With hydrogenchloride; thionyl chloride; potassium tert-butylate; isopropyl alcohol; potassium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1402048-09-2
4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carboxylic acid ethyl ester

: 1402048-16-1
[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-feri-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyrazin-2-yl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

1.2: 20 °C / pH ~ 6

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

2.2: 6 h / 20 °C

With thionyl chloride; isopropyl alcohol; potassium hydroxide; N,N-dimethyl-formamide; In dichloromethane;