2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-tert-butoxycarbonylproline

Base Information

Chemical Name:2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-tert-butoxycarbonylproline
CAS No.:863330-83-0
Molecular Formula:C₂₅H₃₂N₂O₄S
Molecular Weight:456.606
Hs Code.:

Synonyms:2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-tert-butoxycarbonylproline

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Chemical Property of 2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-tert-butoxycarbonylproline

Chemical Property:

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Technology Process of 2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-tert-butoxycarbonylproline

There total 4 articles about 2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-tert-butoxycarbonylproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 863330-82-9
2-(3-methoxyphenyl)-2-(phenylthio)-1-aminoethane

: 863330-83-0
2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-tert-butoxycarbonylproline

Guidance literature:: With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; for 24h;
DOI:10.3390/10010295

Reference yield:

: 3179-09-7,55446-68-9
(E)-1-methoxy-3-(2-nitrovinyl)benzene

: 863330-83-0
2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-tert-butoxycarbonylproline

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / N-isopropylcyclohexylamine / CH₂Cl₂ / 1 h / 20 °C

2: 45 percent / acetic acid; Zn; HCL / 20 °C

3: 20 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; 4-N,N-dimethylaminopyridine / tetrahydrofuran / 24 h

With hydrogenchloride; dmap; N-cyclohexylisopropylamine; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; dichloromethane; 1: Michael addition;
DOI:10.3390/10010295

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 863330-83-0
2(S)-N-[2-(3-methoxyphenyl)-2-(phenylthio)ethanyl]-1-tert-butoxycarbonylproline

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / glacial acetic acid; ammonium acetate / 1 h / Heating

2: 90 percent / N-isopropylcyclohexylamine / CH₂Cl₂ / 1 h / 20 °C

3: 45 percent / acetic acid; Zn; HCL / 20 °C

4: 20 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; 4-N,N-dimethylaminopyridine / tetrahydrofuran / 24 h

With ammonium acetate; hydrogenchloride; dmap; N-cyclohexylisopropylamine; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; dichloromethane; 2: Michael addition;
DOI:10.3390/10010295