2,6-bis(3-methyl-3-hydroxyl-1-butynyl)-4-tert-butylaniline

Base Information

• Chemical Name: 2,6-bis(3-methyl-3-hydroxyl-1-butynyl)-4-tert-butylaniline
• CAS No.: 1244501-47-0
• Molecular Formula: C₂₀H₂₇NO₂
• Molecular Weight: 313.44
• Mol file: 1244501-47-0.mol

Synonyms:2,6-bis(3-methyl-3-hydroxyl-1-butynyl)-4-tert-butylaniline

Chemical Property of 2,6-bis(3-methyl-3-hydroxyl-1-butynyl)-4-tert-butylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-bis(3-methyl-3-hydroxyl-1-butynyl)-4-tert-butylaniline

There total 3 articles about 2,6-bis(3-methyl-3-hydroxyl-1-butynyl)-4-tert-butylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-methyl-but-3-yn-2-ol (115-19-5) + 4-(tert-butyl)-2,5-diiodoaniline (173282-39-8) → 2,6-bis(3-methyl-3-hydroxyl-1-butynyl)-4-tert-butylaniline (1244501-47-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja105121z

Reference yield: 83.0%

2,6-dibromo-4-(tert-butyl)aniline (10546-67-5) + 2-methyl-but-3-yn-2-ol (115-19-5) → 2,6-bis(3-methyl-3-hydroxyl-1-butynyl)-4-tert-butylaniline (1244501-47-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 50 ℃; for 60h; Inert atmosphere;

DOI:10.1039/c3cc47915c

Reference yield:

4-tert-Butylaniline (769-92-6) → 2,6-bis(3-methyl-3-hydroxyl-1-butynyl)-4-tert-butylaniline (1244501-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 60 h / 50 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bromine; In dichloromethane;

DOI:10.1039/c3cc47915c

upstream raw materials:

2-methyl-but-3-yn-2-ol

4-(tert-butyl)-2,5-diiodoaniline

4-tert-Butylaniline

2,6-dibromo-4-(tert-butyl)aniline

Downstream raw materials:

(E)-4-((4-(tert-butyl)-2,6-bis(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)diazenyl)-benzene-1,3-diol