1-Amino-3-propane Hydrochloride

Base Information

• Chemical Name: 1-Amino-3-propane Hydrochloride
• CAS No.: 83948-61-2
• Molecular Formula: C₁₂H₁₈N₂O₂*ClH
• Molecular Weight: 258.748
• Mol file: 83948-61-2.mol

Synonyms:1-Amino-3-propane Hydrochloride

Chemical Property of 1-Amino-3-propane Hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Amino-3-propane Hydrochloride

There total 8 articles about 1-Amino-3-propane Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-<(tert-Butoxycarbonyl)amino>-3-propane (83948-50-9) → 1-Amino-3-propane Hydrochloride (83948-61-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 ℃;

DOI:10.1021/jo00149a005

Reference yield: 47.0%

1-<(tert-Butoxycarbonyl)amino>-3-propane (83948-50-9) → 1-Amino-3-propane Hydrochloride (83948-61-2) + dichlorhydrate de 1-amino-3-(benzyloxyamino)propane (84627-28-1)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 ℃;

Reference yield:

O-benzylhydoxylamine hydrochloride (2687-43-6) → 1-Amino-3-propane Hydrochloride (83948-61-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 60 percent / pyridine / acetonitrile / 1.) 0 deg C, 2.) 24 h, room temperature

2: 78 percent / PPh₃, DEAD / tetrahydrofuran / 1.5 h / Ambient temperature

3: 65 percent / H₂ / 5percent Pd/C / ethyl acetate / 3 h / 0 °C / 760 Torr

4: 97 percent / HCl gas / diethyl ether / 0 °C

With pyridine; hydrogenchloride; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate; acetonitrile;

DOI:10.1021/jo00149a005

upstream raw materials:

1-<(tert-Butoxycarbonyl)amino>-3-propane

3-(tert-butoxycarbonylamino)propanol-O-benzyloxime

1-<(tert-butoxycarbonyl)amino>-3-<(benzyloxy)amino>propane

N-benzyloxycarbonyl-O-benzylhydroxylamine

Downstream raw materials:

N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{1-[3-(acetyl-benzyloxy-amino)-propyl]-3-hydroxy-2,5-dioxo-pyrrolidin-3-yl}-acetamide

N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-(4-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-5-oxo-[1,3]dioxolan-4-yl)-acetamide

schizokinen

N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid methyl ester