(S)-2-Methyl-4-(4-methyl-piperidin-4-yl)-1-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine

Base Information

Chemical Name:(S)-2-Methyl-4-(4-methyl-piperidin-4-yl)-1-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine
CAS No.:306298-11-3
Molecular Formula:C₂₆H₃₄F₃N₃
Molecular Weight:445.571
Hs Code.:

Synonyms:(S)-2-Methyl-4-(4-methyl-piperidin-4-yl)-1-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine

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Chemical Property of (S)-2-Methyl-4-(4-methyl-piperidin-4-yl)-1-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine

Chemical Property:

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Technology Process of (S)-2-Methyl-4-(4-methyl-piperidin-4-yl)-1-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine

There total 8 articles about (S)-2-Methyl-4-(4-methyl-piperidin-4-yl)-1-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 306298-10-2
4-Methyl-4-{(S)-3-methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazin-1-yl}-piperidine-1-carboxylic acid tert-butyl ester

: 306298-11-3
(S)-2-Methyl-4-(4-methyl-piperidin-4-yl)-1-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm0304515

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 306298-11-3
(S)-2-Methyl-4-(4-methyl-piperidin-4-yl)-1-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium isopropoxide / 3 h

1.2: 85 percent / toluene / 20 h / 20 °C

2.1: sodium hexamethyldisilazide / tetrahydrofuran

2.2: tetrahydrofuran / 20 °C

3.1: 36 percent / MgBr₂*OEt₂; sodium triacetoxy borohydride / acetonitrile

4.1: trifluoroacetic acid / CH₂Cl₂ / 20 °C

5.1: titanium isopropoxide / CH₂Cl₂

5.2: CH₂Cl₂

6.1: tetrahydrofuran / 20 °C

7.1: trifluoroacetic acid / CH₂Cl₂

With titanium(IV) isopropylate; sodium hexamethyldisilazane; sodium tris(acetoxy)borohydride; trifluoroacetic acid; magnesium bromide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm0304515

Reference yield:

: 147081-29-6
(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 306298-11-3
(S)-2-Methyl-4-(4-methyl-piperidin-4-yl)-1-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium isopropoxide / 3 h

1.2: 85 percent / toluene / 20 h / 20 °C

2.1: sodium hexamethyldisilazide / tetrahydrofuran

2.2: tetrahydrofuran / 20 °C

3.1: 36 percent / MgBr₂*OEt₂; sodium triacetoxy borohydride / acetonitrile

4.1: trifluoroacetic acid / CH₂Cl₂ / 20 °C

5.1: titanium isopropoxide / CH₂Cl₂

5.2: CH₂Cl₂

6.1: tetrahydrofuran / 20 °C

7.1: trifluoroacetic acid / CH₂Cl₂

With titanium(IV) isopropylate; sodium hexamethyldisilazane; sodium tris(acetoxy)borohydride; trifluoroacetic acid; magnesium bromide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm0304515