benzyl (S)-(1-((2-((tert-butoxycarbonyl)amino)ethyl)amino)-1-oxopropan-2-yl)carbamate

Base Information

Chemical Name:benzyl (S)-(1-((2-((tert-butoxycarbonyl)amino)ethyl)amino)-1-oxopropan-2-yl)carbamate
CAS No.:126166-08-3
Molecular Formula:C₁₈H₂₇N₃O₅
Molecular Weight:365.429
Hs Code.:

Synonyms:benzyl (S)-(1-((2-((tert-butoxycarbonyl)amino)ethyl)amino)-1-oxopropan-2-yl)carbamate

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Chemical Property of benzyl (S)-(1-((2-((tert-butoxycarbonyl)amino)ethyl)amino)-1-oxopropan-2-yl)carbamate

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Technology Process of benzyl (S)-(1-((2-((tert-butoxycarbonyl)amino)ethyl)amino)-1-oxopropan-2-yl)carbamate

There total 1 articles about benzyl (S)-(1-((2-((tert-butoxycarbonyl)amino)ethyl)amino)-1-oxopropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 57260-73-8
N-BOC-1,2-diaminoethane

: 1142-20-7
N-Cbz-Ala

: 126166-08-3
benzyl (S)-(1-((2-((tert-butoxycarbonyl)amino)ethyl)amino)-1-oxopropan-2-yl)carbamate

Guidance literature:: N-Cbz-Ala; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃;

N-BOC-1,2-diaminoethane; In tetrahydrofuran; at 20 ℃; Further stages.;
DOI:10.1021/ja003770j

Reference yield: 97.0%

: 126166-08-3
benzyl (S)-(1-((2-((tert-butoxycarbonyl)amino)ethyl)amino)-1-oxopropan-2-yl)carbamate

: [1-S-(2-aminoethylcarbamoyl)ethyl]carbamic acid benzyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 22h;
DOI:10.1021/ja003770j

Reference yield:

: 126166-08-3
benzyl (S)-(1-((2-((tert-butoxycarbonyl)amino)ethyl)amino)-1-oxopropan-2-yl)carbamate

: 374756-03-3
N-[2-(2-S-benzyloxycarbonylamino-propanoylamino)ethyl] 2-methanesulfanyl succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / concd HCl / methanol / 22 h / 20 °C

2: 77 percent / N-ethylmorpholine; HOBT; EDAC / CH₂Cl₂ / 24 h

With N-ethylmorpholine;; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1021/ja003770j