tert-butyl (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylate

Base Information

• Chemical Name: tert-butyl (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylate
• CAS No.: 1208233-14-0
• Molecular Formula: C₁₈H₂₄O₃
• Molecular Weight: 288.387
• Mol file: 1208233-14-0.mol

Synonyms:tert-butyl (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylate

Chemical Property of tert-butyl (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of tert-butyl (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylate

There total 1 articles about tert-butyl (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 4-iodo-2-(3-methylbut-2-en-1-yl)phenol (151071-03-3) → tert-butyl (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylate (1208233-14-0)

Guidance literature:

With tetrabutyl-ammonium chloride; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In water; N,N-dimethyl-formamide; at 35 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2009.11.007

Reference yield: 85.0%

tert-butyl (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylate (1208233-14-0) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl (E)-3-(4-(tert-butyldimethylsilyloxy)-3-(3-methylbut-2-en-1-yl)phenyl)acrylate

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1021/acs.jafc.9b04835

Reference yield: 62.0%

tert-butyl (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylate (1208233-14-0) → drupanin (53755-58-1,78834-99-8)

Guidance literature:

tert-butyl (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylate; With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2009.11.007

upstream raw materials:

tert-Butyl acrylate

4-iodo-2-(3-methylbut-2-en-1-yl)phenol

Downstream raw materials:

drupanin