2-(4-chloro-3-trifluoromethylphenoxy)-3-(4-fluorophenyl)-6-methyl-5-nitropyridine

Base Information

Chemical Name:2-(4-chloro-3-trifluoromethylphenoxy)-3-(4-fluorophenyl)-6-methyl-5-nitropyridine
CAS No.:1049707-76-7
Molecular Formula:C₁₉H₁₁ClF₄N₂O₃
Molecular Weight:426.755
Hs Code.:

Synonyms:2-(4-chloro-3-trifluoromethylphenoxy)-3-(4-fluorophenyl)-6-methyl-5-nitropyridine

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Chemical Property of 2-(4-chloro-3-trifluoromethylphenoxy)-3-(4-fluorophenyl)-6-methyl-5-nitropyridine

Chemical Property:

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Technology Process of 2-(4-chloro-3-trifluoromethylphenoxy)-3-(4-fluorophenyl)-6-methyl-5-nitropyridine

There total 6 articles about 2-(4-chloro-3-trifluoromethylphenoxy)-3-(4-fluorophenyl)-6-methyl-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1049707-75-6
3-bromo-2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitropyridine

: 1765-93-1
4-fluoroboronic acid

: 1049707-76-7
2-(4-chloro-3-trifluoromethylphenoxy)-3-(4-fluorophenyl)-6-methyl-5-nitropyridine

Guidance literature:: With potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; at 20 - 100 ℃; for 6.75h;

Reference yield:

: 500587-45-1
3,5-dibromo-2-hydroxy-6-methylpyridine

: 1049707-76-7
2-(4-chloro-3-trifluoromethylphenoxy)-3-(4-fluorophenyl)-6-methyl-5-nitropyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -80 - -74 °C / Cooling with ether-dry ice

1.2: -78 - 20 °C

2.1: nitric acid / water / 3.5 h / 0 - 20 °C

2.2: pH 4

3.1: trichlorophosphate / 7 h / Heating / reflux

4.1: sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane / 1,4-dioxane / 0.5 h / 20 °C

4.2: 22 h / 20 °C

5.1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane; water / 6.75 h / 20 - 100 °C

With potassium phosphate; n-butyllithium; nitric acid; sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane; trichlorophosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; hexane; water;

Reference yield:

: 874493-25-1
3-bromo-6-methyl-5-nitro-pyridin-2-ol

: 1049707-76-7
2-(4-chloro-3-trifluoromethylphenoxy)-3-(4-fluorophenyl)-6-methyl-5-nitropyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 7 h / Heating / reflux

2.1: sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane / 1,4-dioxane / 0.5 h / 20 °C

2.2: 22 h / 20 °C

3.1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane; water / 6.75 h / 20 - 100 °C

With potassium phosphate; sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane; trichlorophosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water;