C₁₅H₁₂N₂OS

Base Information

• Chemical Name: C₁₅H₁₂N₂OS
• CAS No.: 1616400-79-3
• Molecular Formula: C₁₅H₁₂N₂OS
• Molecular Weight: 268.339
• Mol file: 1616400-79-3.mol

Synonyms:C₁₅H₁₂N₂OS

Chemical Property of C₁₅H₁₂N₂OS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₂N₂OS

There total 4 articles about C₁₅H₁₂N₂OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

5-bromo-1,3-thiazole (3034-55-7) + 1-benzyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2(1H)-one (1594127-49-7) → C15H12N2OS (1616400-79-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 16h;

Reference yield:

benzyl bromide (100-39-0) → C15H12N2OS (1616400-79-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 3 h / 70 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

1-benzyl-5-bromo-1,2-dihydropyridin-2-one (217448-53-8) → C15H12N2OS (1616400-79-3)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

upstream raw materials:

benzyl bromide

1-benzyl-5-bromo-1,2-dihydropyridin-2-one

5-bromo-1,3-thiazole

1-benzyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2(1H)-one

Refernces