C₃₀H₃₁BrN₄O₈S

Base Information

• Chemical Name: C₃₀H₃₁BrN₄O₈S
• CAS No.: 1185730-68-0
• Molecular Formula: C₃₀H₃₁BrN₄O₈S
• Molecular Weight: 687.568
• Mol file: 1185730-68-0.mol

Synonyms:C₃₀H₃₁BrN₄O₈S

Chemical Property of C₃₀H₃₁BrN₄O₈S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₁BrN₄O₈S

There total 8 articles about C₃₀H₃₁BrN₄O₈S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate (1185730-59-9) + 1,1'-carbonyldiimidazole (530-62-1) → C30H31BrN4O8S (1185730-68-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/ja809933h

Reference yield:

benzenesulfonyl chloride (98-09-9) → C30H31BrN4O8S (1185730-68-0)

Guidance literature:

Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14.16 h / 0 - 20 °C / Inert atmosphere

2: selenium(IV) oxide / 1,4-dioxane / 24 h / 80 °C / Inert atmosphere

3: water; indium; ammonium chloride / tetrahydrofuran / 3 h / Inert atmosphere

4: 2,6-dimethylpyridine; sodium periodate; potassium osmate(VI) dihydrate / 1,4-dioxane; water / 25 °C / Inert atmosphere

5: sodium tris(acetoxy)borohydride / acetic acid / methanol / 20 h / 25 °C / Inert atmosphere

6: dichloromethane / 6.08 h / 0 - 20 °C / Inert atmosphere

7: dichloromethane / 4 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; selenium(IV) oxide; potassium osmate(VI) dihydrate; indium; sodium periodate; water; sodium tris(acetoxy)borohydride; ammonium chloride; N-ethyl-N,N-diisopropylamine; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

8-bromo-2-(1-hydroxy-3-oxopropyl)quinolin-7-yl benzenesulfonate (1185730-56-6) → C30H31BrN4O8S (1185730-68-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / acetic acid / methanol / 20 h / 25 °C / Inert atmosphere

2: dichloromethane / 6.08 h / 0 - 20 °C / Inert atmosphere

3: dichloromethane / 4 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; acetic acid; In methanol; dichloromethane;

upstream raw materials:

methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate

1,1'-carbonyldiimidazole

benzenesulfonyl chloride

8-bromo-2-(1-hydroxy-3-(methylamino)propyl)quinolin-7-yl benzenesulfonate

Downstream raw materials:

methyl 14-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-17-methyl-5,12,18-trioxo-13-oxa-4,11,17-triazatricos-1-yn-23-oate