[4-(Hydroxymethyl)-1-trityl-1H-imidazol-5-YL]methanol

Base Information

• Chemical Name: [4-(Hydroxymethyl)-1-trityl-1H-imidazol-5-YL]methanol
• CAS No.: 77134-74-8
• Molecular Formula: C24H22 N2 O2
• Molecular Weight: 370.451
• Hs Code.: 2933290090
• DSSTox Substance ID: DTXSID60512871
• Wikidata: Q72514773
• Mol file: 77134-74-8.mol

Synonyms:77134-74-8;[4-(HYDROXYMETHYL)-1-TRITYL-1H-IMIDAZOL-5-YL]METHANOL;[5-(hydroxymethyl)-1-tritylimidazol-4-yl]methanol;4,5-dihydroxymethyl-1-triphenylmethylimidazole;(1-trityl-1H-imidazole-4,5-diyl)dimethanol;DTXSID60512871;AMY19302;AKOS027381539;FT-0708951;[1-(Triphenylmethyl)-1H-imidazole-4,5-diyl]dimethanol

Chemical Property of [4-(Hydroxymethyl)-1-trityl-1H-imidazol-5-YL]methanol

Chemical Property:

• Vapor Pressure: 6.15E-14mmHg at 25°C
• Melting Point: 192-193℃
• Refractive Index: 1.618
• Boiling Point: 572.3ºC at 760 mmHg
• Flash Point: 299.9ºC
• PSA: 58.28000
• Density: 1.15g/cm3
• LogP: 3.70790
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 370.168127949
• Heavy Atom Count: 28
• Complexity: 422

Purity/Quality:

98%Min ^*data from raw suppliers

[4-(Hydroxymethyl)-1-trityl-1H-imidazol-5-yl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=NC(=C4CO)CO

Technology Process of [4-(Hydroxymethyl)-1-trityl-1H-imidazol-5-YL]methanol

There total 5 articles about [4-(Hydroxymethyl)-1-trityl-1H-imidazol-5-YL]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

dimethyl 1-triphenylmethylimidazole-4,5-dicarboxylate (77134-73-7) → 4,5-dihydroxymethyl-1-triphenylmethylimidazole (77134-74-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; 1.) 0 degC 30 min., 2.) R_.T_. 3 h;

DOI:10.1139/v82-107

Reference yield:

dimethyl imidazole-4,5-dicarboxylate (3304-70-9) → 4,5-dihydroxymethyl-1-triphenylmethylimidazole (77134-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / triethylamine / dimethylformamide / 4 h / Ambient temperature

2: 85 percent / lithium aluminium hydride / tetrahydrofuran / 1.) 0 degC 30 min., 2.) R_.T_. 3 h

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1139/v82-107

Reference yield:

trityl chloride (76-83-5) → 4,5-dihydroxymethyl-1-triphenylmethylimidazole (77134-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / triethylamine / dimethylformamide / 4 h / Ambient temperature

2: 85 percent / lithium aluminium hydride / tetrahydrofuran / 1.) 0 degC 30 min., 2.) R_.T_. 3 h

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1139/v82-107

upstream raw materials:

dimethyl 1-triphenylmethylimidazole-4,5-dicarboxylate

dimethyl imidazole-4,5-dicarboxylate

trityl chloride

Downstream raw materials:

4-acetoxymethyl-5-hydroxymethyl-1-triphenylmethylimidazole

4,5-dihydroxymethylimidazole

triphenylmethyl alcohol

5-(4-hydroxymethyl-1-triphenylmethyl)imidazolecarboxaldehyde