N-(3-aminopropyl)-7,7-bis[(4S)-4,5-dihydro-4-phenyloxazol-2-yl]octanamide

Base Information

• Chemical Name: N-(3-aminopropyl)-7,7-bis[(4S)-4,5-dihydro-4-phenyloxazol-2-yl]octanamide
• CAS No.: 1415964-15-6
• Molecular Formula: C₂₉H₃₈N₄O₃
• Molecular Weight: 490.646
• Mol file: 1415964-15-6.mol

Synonyms:N-(3-aminopropyl)-7,7-bis[(4S)-4,5-dihydro-4-phenyloxazol-2-yl]octanamide

Chemical Property of N-(3-aminopropyl)-7,7-bis[(4S)-4,5-dihydro-4-phenyloxazol-2-yl]octanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-aminopropyl)-7,7-bis[(4S)-4,5-dihydro-4-phenyloxazol-2-yl]octanamide

There total 4 articles about N-(3-aminopropyl)-7,7-bis[(4S)-4,5-dihydro-4-phenyloxazol-2-yl]octanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C27H32N2O4 (1415964-26-9) + Trimethylenediamine (109-76-2,54018-94-9) → N-(3-aminopropyl)-7,7-bis[(4S)-4,5-dihydro-4-phenyloxazol-2-yl]octanamide (1415964-15-6)

Guidance literature:

at 20 ℃; for 48h;

DOI:10.1002/hlca.201200380

Reference yield:

C24H32N2O4 → N-(3-aminopropyl)-7,7-bis[(4S)-4,5-dihydro-4-phenyloxazol-2-yl]octanamide (1415964-15-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap; triethylamine; p-toluenesulfonyl chloride / dichloromethane / 48 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C

2.2: 6 h / 0 - 20 °C / Reflux

3.1: 48 h / 20 °C

With dmap; n-butyllithium; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/hlca.201200380

Reference yield:

(4S,4’S)-2,2’-ethylidenebis[4,5-dihydro-4-phenyloxazole] (862605-37-6) → N-(3-aminopropyl)-7,7-bis[(4S)-4,5-dihydro-4-phenyloxazol-2-yl]octanamide (1415964-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C

1.2: 6 h / 0 - 20 °C / Reflux

2.1: 48 h / 20 °C

With n-butyllithium; In tetrahydrofuran;

DOI:10.1002/hlca.201200380

upstream raw materials:

(4S,4’S)-2,2’-ethylidenebis[4,5-dihydro-4-phenyloxazole]

C₂₇H₃₂N₂O₄

Trimethylenediamine

(2S)-2-phenylglycinol