5-[1-Hydroxy-2-(4-methoxy-phenyl)-ethylidene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

Base Information

Chemical Name:5-[1-Hydroxy-2-(4-methoxy-phenyl)-ethylidene]-2,2-dimethyl-[1,3]dioxane-4,6-dione
CAS No.:153525-08-7
Molecular Formula:C₁₅H₁₆O₆
Molecular Weight:292.288
Hs Code.:

Synonyms:5-[1-Hydroxy-2-(4-methoxy-phenyl)-ethylidene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

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Chemical Property of 5-[1-Hydroxy-2-(4-methoxy-phenyl)-ethylidene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

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Technology Process of 5-[1-Hydroxy-2-(4-methoxy-phenyl)-ethylidene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

There total 1 articles about 5-[1-Hydroxy-2-(4-methoxy-phenyl)-ethylidene]-2,2-dimethyl-[1,3]dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 2033-24-1
cycl-isopropylidene malonate

: 153525-08-7
5-[1-Hydroxy-2-(4-methoxy-phenyl)-ethylidene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

Guidance literature:: 4-Methoxyphenylacetic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; for 0.5h;

cycl-isopropylidene malonate; In dichloromethane; for 12h;
DOI:10.1007/s11172-011-0019-9

Reference yield:

: 64-17-5
ethanol

: 153525-08-7
5-[1-Hydroxy-2-(4-methoxy-phenyl)-ethylidene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

: 718-08-1
ethyl 3-oxo-4-phenylbutyrate

Guidance literature:: Reflux;
DOI:10.1016/j.ejmech.2014.07.033

Reference yield:

: 153525-08-7
5-[1-Hydroxy-2-(4-methoxy-phenyl)-ethylidene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

: (R)-(+)-4-(4-Methoxybenzyl)oxetan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 3 h / Heating

2: 96 percent / H₂ / (R)-BINAP-Ru(II) / ethanol / 80 °C / 76000 - 83600 Torr

3: 96 percent / aq. KOH / ethanol / 24 h / 0 °C

4: 95 percent / triphenylphosphine / CHCl₃ / Ambient temperature

5: 80 percent / Hg(CH₃SO₃)2 / acetonitrile / 0.17 h / 50 °C

With potassium hydroxide; hydrogen; Mercury(II) methanesulphonate; triphenylphosphine; (R)-BINAP-Ru(II); In ethanol; chloroform; acetonitrile;
DOI:10.1021/jo00079a049