Imidazo[1,2-a]pyrazine-2-carboxamide

Base Information

• Chemical Name: Imidazo[1,2-a]pyrazine-2-carboxamide
• CAS No.: 77124-59-5
• Molecular Formula: C₇H₆N₄O
• Molecular Weight: 162.151
• Hs Code.: 2934999090
• ChEMBL ID: CHEMBL302727
• DSSTox Substance ID: DTXSID50506486
• Mol file: 77124-59-5.mol

Synonyms:imidazo[1,2-a]pyrazine-2-carboxamide;77124-59-5;CHEMBL302727;SCHEMBL12466875;DTXSID50506486;AKOS024321194;Imidazo[1,2-a]pyrazine-2-carboxamide(9ci)

Chemical Property of Imidazo[1,2-a]pyrazine-2-carboxamide

Chemical Property:

• Melting Point: 280 °C (decomp)
• PKA: 11.72±0.50(Predicted)
• PSA: 73.28000
• Density: 1.58±0.1 g/cm3(Predicted)
• LogP: 0.52850
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 162.05416083
• Heavy Atom Count: 12
• Complexity: 196

Purity/Quality:

98% ^*data from raw suppliers

IMIDAZO[1,2-A]PYRAZINE-2-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C=C(N=C2C=N1)C(=O)N

Technology Process of Imidazo[1,2-a]pyrazine-2-carboxamide

There total 1 articles about Imidazo[1,2-a]pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl imidazo[1,2-a]pyrazine-2-carboxylate (77112-52-8) → imidazo <1,2-a>pyrazine-2-carboxamide (77124-59-5)

Guidance literature:

With ammonium hydroxide; for 1h; Heating;

DOI:10.1021/jm00368a018

Reference yield: 85.0%

imidazo <1,2-a>pyrazine-2-carboxamide (77124-59-5) → imidazo<1,2-a>pyrazinecarbonitrile-2 (87597-31-7)

Guidance literature:

With trichlorophosphate; for 1h; Heating;

Reference yield:

imidazo <1,2-a>pyrazine-2-carboxamide (77124-59-5) → C14H11N7O2 (89331-76-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / POCl₃ / 1 h / Heating

2: 80 percent / hydrate d'hydrazine / ethanol / 3 h / Heating

3: 95 percent / ethanol

With hydrazine hydrate; trichlorophosphate; In ethanol;

upstream raw materials:

ethyl imidazo[1,2-a]pyrazine-2-carboxylate

Downstream raw materials:

imidazo<1,2-a>pyrazinecarbonitrile-2

C₁₄H₁₂N₆

C₁₃H₁₆N₆

C₁₅H₁₄N₆O

Refernces

• 1、 Bonnet,Sablayrolles,Chapat,et al.. "Imidazo[1,2-a]pyrazine-2 carboxyamidrazones: Synthesis and antibacterial activity". . p. 413 - 417. Retrieved 2007/10/02.