87597-31-7Relevant academic research and scientific papers
Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties
Sablayrolles,Cros,Milhavet,Rechenq,Chapat,Boucard,Serrano,McNeill
, p. 206 - 212 (2007/10/02)
A series of imidazo[1,2-a]pyrazine derivatives was synthesized by condensation of α-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo[1,2-a]pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an increase in the cyclic AMP tissue concentration. Potentiation of the isoproterenol positive inotropic effect of 5-bromoimidazo[1,2-a]pyrazine and the lack of blockade of the 5-bromoimidazo[1,2-a]pyrazine positive inotropic effect by propranolol suggested phosphodiesterase-inhibiting properties.
Imidazo[1,2-a]pyrazine-2 carboxyamidrazones: Synthesis and antibacterial activity
Bonnet,Sablayrolles,Chapat,et al.
, p. 413 - 417 (2007/10/02)
Fifteen new amidrazones, derivatives of imidazo[1,2-a]pyrazine, are prepared and tested for antimycobacteria and antibacteria potencies. Some substitutions enhance the activity of imidazo[1,2-a]pyrazine-2-amidrazone against tuberculous mycobacteria. One c
