7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol

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Chemical Name:7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol
CAS No.:1196886-17-5
Molecular Formula:C₂₃H₂₄N₄O₆S₂
Molecular Weight:516.599
Hs Code.:

Synonyms:7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol

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Chemical Property of 7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol

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Technology Process of 7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol

There total 10 articles about 7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1196886-14-2
4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

: 1196886-17-5
7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 12h;

Reference yield:

: 333388-03-7
4,6-dichloro-2-(methylsulfanyl)pyrimidin-5-amine

: 1196886-17-5
7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: n-butyllithium / tetrahydrofuran / -78 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

4: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.33 h / 180 °C / Microwave irradiation

5: oxone / dichloromethane / 36 h / 20 °C

6: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C

With oxone; n-butyllithium; hydrogen; potassium acetate; sodium hydride; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 86604-78-6
(4-methoxy-3,5-dimethylpyridin-2-yl)methanol

: 1196886-17-5
7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: manganese(IV) oxide / chloroform / 0.17 h / 20 °C

2: potassium carbonate / ethanol / 4 h / 70 °C

3: Diisobutyl adipate / tetrahydrofuran / -78 - -7 °C

4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

5: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.33 h / 180 °C / Microwave irradiation

6: oxone / dichloromethane / 36 h / 20 °C

7: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C

With manganese(IV) oxide; oxone; Diisobutyl adipate; hydrogen; potassium acetate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; toluene;