4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

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Chemical Name:4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine
CAS No.:1196886-14-2
Molecular Formula:C₃₀H₃₀N₄O₆S₂
Molecular Weight:606.723
Hs Code.:

Synonyms:4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

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Chemical Property of 4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

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Technology Process of 4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

There total 10 articles about 4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1196886-12-0
4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylthio)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

: 1196886-14-2
4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: With oxone; In dichloromethane; at 20 ℃; for 36h;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1196886-14-2
4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: n-butyllithium / tetrahydrofuran / -78 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

4: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.33 h / 180 °C / Microwave irradiation

5: oxone / dichloromethane / 36 h / 20 °C

With oxone; n-butyllithium; potassium acetate; sodium hydride; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 86604-78-6
(4-methoxy-3,5-dimethylpyridin-2-yl)methanol

: 1196886-14-2
4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: manganese(IV) oxide / chloroform / 0.17 h / 20 °C

2: potassium carbonate / ethanol / 4 h / 70 °C

3: Diisobutyl adipate / tetrahydrofuran / -78 - -7 °C

4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

5: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.33 h / 180 °C / Microwave irradiation

6: oxone / dichloromethane / 36 h / 20 °C

With manganese(IV) oxide; oxone; Diisobutyl adipate; potassium acetate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; chloroform; toluene;