(E)-ethyl 3-(1'-(4''-hydroxyphenyl)-3'-phenyl-1'H-pyrazol-4'-yl)acrylate

Base Information

Chemical Name:(E)-ethyl 3-(1'-(4''-hydroxyphenyl)-3'-phenyl-1'H-pyrazol-4'-yl)acrylate
CAS No.:1236289-21-6
Molecular Formula:C₂₀H₁₈N₂O₃
Molecular Weight:334.375
Hs Code.:

Synonyms:(E)-ethyl 3-(1'-(4''-hydroxyphenyl)-3'-phenyl-1'H-pyrazol-4'-yl)acrylate

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Chemical Property of (E)-ethyl 3-(1'-(4''-hydroxyphenyl)-3'-phenyl-1'H-pyrazol-4'-yl)acrylate

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Technology Process of (E)-ethyl 3-(1'-(4''-hydroxyphenyl)-3'-phenyl-1'H-pyrazol-4'-yl)acrylate

There total 3 articles about (E)-ethyl 3-(1'-(4''-hydroxyphenyl)-3'-phenyl-1'H-pyrazol-4'-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1236289-16-9
(E)-ethyl 3-(1'-(4''-methoxyphenyl)-3'-phenyl-1'H-pyrazol-4'-yl)acrylate

: 1236289-21-6
(E)-ethyl 3-(1'-(4''-hydroxyphenyl)-3'-phenyl-1'H-pyrazol-4'-yl)acrylate

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 17h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.04.076

Reference yield:

: 1020240-78-1
1-(4'-methoxyphenyl)-3-phenyl-1H-pyrazole-4-carbaldehyde

: 1236289-21-6
(E)-ethyl 3-(1'-(4''-hydroxyphenyl)-3'-phenyl-1'H-pyrazol-4'-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / Reflux; Inert atmosphere

2: boron tribromide / dichloromethane / 17 h / -78 - 20 °C / Inert atmosphere

With boron tribromide; In dichloromethane; acetonitrile; 1: |Wittig Olefination;
DOI:10.2174/157340612802084252

Reference yield:

: 98-86-2
acetophenone

: 1236289-21-6
(E)-ethyl 3-(1'-(4''-hydroxyphenyl)-3'-phenyl-1'H-pyrazol-4'-yl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; triethylamine / ethanol / 20 °C / Inert atmosphere

2: 1,3,5-trichloro-2,4,6-triazine / 2 h / 20 °C / Inert atmosphere

3: acetonitrile / Reflux; Inert atmosphere

4: boron tribromide / dichloromethane / 17 h / -78 - 20 °C / Inert atmosphere

With 1,3,5-trichloro-2,4,6-triazine; boron tribromide; acetic acid; triethylamine; In ethanol; dichloromethane; acetonitrile; 3: |Wittig Olefination;
DOI:10.2174/157340612802084252