2-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-{[(2-hydroxyethyl)(methyl)amino]methyl}phenol

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Chemical Name:2-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-{[(2-hydroxyethyl)(methyl)amino]methyl}phenol
CAS No.:1376513-98-2
Molecular Formula:C₂₂H₃₅N₅O₃
Molecular Weight:417.552
Hs Code.:

Synonyms:2-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-{[(2-hydroxyethyl)(methyl)amino]methyl}phenol

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Chemical Property of 2-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-{[(2-hydroxyethyl)(methyl)amino]methyl}phenol

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Technology Process of 2-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-{[(2-hydroxyethyl)(methyl)amino]methyl}phenol

There total 8 articles about 2-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-{[(2-hydroxyethyl)(methyl)amino]methyl}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376514-18-9
(3S)-3-{[2-amino-5-(2-methoxy-4-{[(2-methoxyethyl)(methyl)amino]methyl}benzyl)-6-methylpyrimidin-4-yl]amino}hexan-1-ol

: 1376513-98-2
2-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-{[(2-hydroxyethyl)(methyl)amino]methyl}phenol

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 104436-60-4
4-bromomethyl-3-methoxybenzonitrile

: 1376513-98-2
2-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-{[(2-hydroxyethyl)(methyl)amino]methyl}phenol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 16 h / 70 °C

2.1: methanol / 16 h / 65 °C

3.1: trichlorophosphate / 16 h / 100 °C

3.2: 1 h / 50 °C / pH 7

4.1: 1,4-dioxane / 9 h / 180 °C / Microwave irradiation

5.1: pyridine; acetic acid; sodium hypophosphite monohydrate / Raney nickel / water / 16 h / 45 °C

6.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 0 °C / Molecular sieve

7.1: boron tribromide / dichloromethane / 16 h / 20 °C

With pyridine; sodium hypophosphite monohydrate; boron tribromide; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; trichlorophosphate; Raney nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; mineral oil;

Reference yield:

: 1376514-13-4
ethyl 2-(4-cyano-2-methoxybenzyl)-3-oxobutanoate

: 1376513-98-2
2-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-5-{[(2-hydroxyethyl)(methyl)amino]methyl}phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 16 h / 65 °C

2.1: trichlorophosphate / 16 h / 100 °C

2.2: 1 h / 50 °C / pH 7

3.1: 1,4-dioxane / 9 h / 180 °C / Microwave irradiation

4.1: pyridine; acetic acid; sodium hypophosphite monohydrate / Raney nickel / water / 16 h / 45 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 0 °C / Molecular sieve

6.1: boron tribromide / dichloromethane / 16 h / 20 °C

With pyridine; sodium hypophosphite monohydrate; boron tribromide; sodium tris(acetoxy)borohydride; acetic acid; trichlorophosphate; Raney nickel; In 1,4-dioxane; methanol; dichloromethane; water;