[benzyloxycarbonylaminoacetyl-(3-methoxyphenyl)amino]acetic acid tert-butyl ester

Base Information

• Chemical Name: [benzyloxycarbonylaminoacetyl-(3-methoxyphenyl)amino]acetic acid tert-butyl ester
• CAS No.: 195711-94-5
• Molecular Formula: C₂₃H₂₈N₂O₆
• Molecular Weight: 428.485

Synonyms:[benzyloxycarbonylaminoacetyl-(3-methoxyphenyl)amino]acetic acid tert-butyl ester

Chemical Property of [benzyloxycarbonylaminoacetyl-(3-methoxyphenyl)amino]acetic acid tert-butyl ester

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Technology Process of [benzyloxycarbonylaminoacetyl-(3-methoxyphenyl)amino]acetic acid tert-butyl ester

There total 3 articles about [benzyloxycarbonylaminoacetyl-(3-methoxyphenyl)amino]acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-Anisidine (536-90-3,918666-97-4) → [benzyloxycarbonylaminoacetyl-(3-methoxyphenyl)amino]acetic acid tert-butyl ester (195711-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / HOBt, Et₃N, DCC / dimethylformamide / 16 h / Ambient temperature

2: 1.) NaH / 1.) THF, 5 min, 2.) THF, RT, 30 min

With sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(97)00076-X

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → [benzyloxycarbonylaminoacetyl-(3-methoxyphenyl)amino]acetic acid tert-butyl ester (195711-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / HOBt, Et₃N, DCC / dimethylformamide / 16 h / Ambient temperature

2: 1.) NaH / 1.) THF, 5 min, 2.) THF, RT, 30 min

With sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(97)00076-X

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) + [(3-methoxyphenylcarbamoyl)methyl]carbamic acid (195711-92-3) → [benzyloxycarbonylaminoacetyl-(3-methoxyphenyl)amino]acetic acid tert-butyl ester (195711-94-5)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, 5 min, 2.) THF, RT, 30 min;

DOI:10.1016/S0968-0896(97)00076-X

upstream raw materials:

bromoacetic acid tert-butyl ester

[(3-methoxyphenylcarbamoyl)methyl]carbamic acid

m-Anisidine

N-(Benzyloxycarbonyl)glycine

Downstream raw materials:

[(3-methoxyphenyl)-({3-[3-({3-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]propyl}carbamoyloxymethyl)phenyl]ureido}acetyl)amino]acetic acid tert-butyl ester

((3-Methoxy-phenyl)-{2-[3-(3-{3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propylcarbamoyloxymethyl}-phenyl)-ureido]-acetyl}-amino)-acetic acid

4-[3-(3-{[tert-butoxycarbonylmethyl-(3-methoxyphenyl)carbamoyl]methyl}ureido)benzyloxycarbonylamino]butyric acid methyl ester

[(2-Amino-acetyl)-(3-methoxy-phenyl)-amino]-acetic acid tert-butyl ester

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