(E)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone

Base Information

Chemical Name:(E)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone
CAS No.:132619-20-6
Molecular Formula:C₃₀H₄₅FN₂O₈SSi₂
Molecular Weight:668.931
Hs Code.:

(E)-1-<2-deoxy-2-<fluoro(phenylsulfonyl)methylene>-3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone

Synonyms:(E)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone

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Chemical Property of (E)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone

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Technology Process of (E)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone

There total 2 articles about (E)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 20808-12-2
fluoromethyl phenyl sulfone

: 113648-22-9
4-ethoxy-1-<3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-2-pentulofuranosyl>-2(1H)-pyrimidinone

: 132619-20-6
(E)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone

: 132619-21-7
(Z)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone

Guidance literature:: With diethyl chlorophosphate; lithium hexamethyldisilazane;
DOI:10.1021/ja00019a061

Reference yield:

: 20808-12-2
fluoromethyl phenyl sulfone

: 132619-20-6
(E)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1M lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C

2: 560 mg / tetrahydrofuran / 2 h / 0 °C

With lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/0040-4020(95)00911-Q

Reference yield:

: 132619-20-6
(E)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone

: 130306-01-3,171233-40-2
(Z)-2'-deoxy-2'-(fluoromethylene)cytidine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); ammonia; tri-n-butyl-tin hydride; cesium fluoride; Yield given. Multistep reaction; 1.) benzene, 2.) methanol;
DOI:10.1021/ja00019a061