Technology Process of 2'-benzyloxy-3'-chloro-4',5'-dimethylisonitrosoacetanilide
There total 4 articles about 2'-benzyloxy-3'-chloro-4',5'-dimethylisonitrosoacetanilide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
chloral hydrate; 2-benzyloxy-3-chloro-4,5-dimethylaniline;
With
hydrogenchloride;
In
water; N,N-dimethyl-formamide;
at 20 - 105 ℃;
With
hydroxylamine hydrochloride;
In
water; N,N-dimethyl-formamide;
at 105 ℃;
for 1h;
DOI:10.1016/S0223-5234(99)00220-2
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 36 percent / 90 percent HNO3 / CH2Cl2 / 1.5 h / 2 - 20 °C
2.1: 77 percent / Cl2 / CHCl3 / 26 h
3.1: 91 percent / K2CO3 / dimethylformamide / 8 h / 20 °C
4.1: 79 percent / CuCl; KBH4 / methanol / 2 °C
5.1: aq. HCl / dimethylformamide; H2O / 20 - 105 °C
5.2: 47 percent / NH2OH*HCl / H2O; dimethylformamide / 1 h / 105 °C
With
hydrogenchloride; potassium borohydride; nitric acid; chlorine; potassium carbonate; copper(l) chloride;
In
methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
1.1: Nitration / 2.1: Chlorination / 3.1: Etherification / 4.1: Reduction / 5.1: Condensation / 5.2: Condensation;
DOI:10.1016/S0223-5234(99)00220-2
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 77 percent / Cl2 / CHCl3 / 26 h
2.1: 91 percent / K2CO3 / dimethylformamide / 8 h / 20 °C
3.1: 79 percent / CuCl; KBH4 / methanol / 2 °C
4.1: aq. HCl / dimethylformamide; H2O / 20 - 105 °C
4.2: 47 percent / NH2OH*HCl / H2O; dimethylformamide / 1 h / 105 °C
With
hydrogenchloride; potassium borohydride; chlorine; potassium carbonate; copper(l) chloride;
In
methanol; chloroform; water; N,N-dimethyl-formamide;
1.1: Chlorination / 2.1: Etherification / 3.1: Reduction / 4.1: Condensation / 4.2: Condensation;
DOI:10.1016/S0223-5234(99)00220-2
