(R)-3-[4-(4-morpholin-4-ylmethylbenzyloxy)-1-oxo-1,3-dihydroisoindol-2-yl]piperidine-2,6-dione

Base Information

Chemical Name:(R)-3-[4-(4-morpholin-4-ylmethylbenzyloxy)-1-oxo-1,3-dihydroisoindol-2-yl]piperidine-2,6-dione
CAS No.:1323403-22-0
Molecular Formula:C₂₅H₂₇N₃O₅
Molecular Weight:449.506
Hs Code.:

Synonyms:(R)-3-[4-(4-morpholin-4-ylmethylbenzyloxy)-1-oxo-1,3-dihydroisoindol-2-yl]piperidine-2,6-dione

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Chemical Property of (R)-3-[4-(4-morpholin-4-ylmethylbenzyloxy)-1-oxo-1,3-dihydroisoindol-2-yl]piperidine-2,6-dione

Chemical Property:

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Technology Process of (R)-3-[4-(4-morpholin-4-ylmethylbenzyloxy)-1-oxo-1,3-dihydroisoindol-2-yl]piperidine-2,6-dione

There total 11 articles about (R)-3-[4-(4-morpholin-4-ylmethylbenzyloxy)-1-oxo-1,3-dihydroisoindol-2-yl]piperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1323408-08-7
(R)-4-carbamoyl-4-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-butyric acid benzyl ester

: 1323403-22-0
(R)-3-[4-(4-morpholin-4-ylmethylbenzyloxy)-1-oxo-1,3-dihydroisoindol-2-yl]piperidine-2,6-dione

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 1323402-36-3
3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione

: 1323403-33-3
(S)-3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione

: 1323403-22-0
(R)-3-[4-(4-morpholin-4-ylmethylbenzyloxy)-1-oxo-1,3-dihydroisoindol-2-yl]piperidine-2,6-dione

Guidance literature:: Resolution of racemate;

Reference yield:

: 1061604-41-8
3-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione

: 1323403-33-3
(S)-3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione

: 1323403-22-0
(R)-3-[4-(4-morpholin-4-ylmethylbenzyloxy)-1-oxo-1,3-dihydroisoindol-2-yl]piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.75 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C

3.1: Resolution of racemate

With di-isopropyl azodicarboxylate; potassium tert-butylate; In tetrahydrofuran;