1323403-33-3

Usage

Uses

Used in Pharmaceutical Industry:
CC220 is used as an anti-inflammatory agent for its capacity to mitigate inflammation by inhibiting the CCR1 receptor, thereby reducing immune cell activity at sites of inflammation.
Used in Autoimmune Disease Treatment:
In conditions such as rheumatoid arthritis and multiple sclerosis, CC220 is utilized as a therapeutic agent to manage the disease by dampening the immune system's overactivity and lessening inflammation.
Used in Preclinical Research:
CC220 serves as a subject of study in preclinical trials to evaluate its efficacy in reducing inflammation and immune system activity, providing insights into its potential as a treatment for inflammatory and autoimmune diseases.
Further research and clinical trials are essential to explore the full therapeutic potential of CC220 in treating a range of inflammatory and autoimmune conditions, ensuring its safe and effective application in medical practice.

Upstream product

• 55289-05-9 methyl 3-hydroxy-2-methylbenzoate 
• 359629-73-5 3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-benzoic acid methyl ester 
• 1323407-17-5 2-bromomethyl-3-(tert-butyl-dimethyl-silanyloxy)-benzoic acid methyl ester 
• 1323407-16-4 4-carbamoyl-4-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-butyric acid methyl ester 
• 603-80-5 3-hydroxy 2-methylbenzoic acid 
• 623-24-5 1,4-bis(bromomethyl)benzene 
• 1323290-64-7 (S)-methyl 4,5-diamino-5-oxopentanoate hydrochloride 
• 1323407-21-1 4-carbamoyl-4-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-butyric acid methyl ester 
• 1560609-43-9 (S)-tert-butyl 5-amino-4-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate 
• 1560678-70-7 (S)-1-benzyl-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione 
• 91271-65-7 (4-morpholin-4-ylmethyl-phenyl)-methanol 
• 1061604-41-8 3-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione 
• 1323402-36-3 3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione 
• 1560678-66-1 (S)-methyl 5-(benzylamino)-4-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate 

Downstream Products

• 1620872-34-5 C₂₅H₂₂⁽²⁾H₅N₃O₅ 
• 1620872-35-6 C₂₅H₂₂⁽²⁾H₅N₃O₅ 

Relevant academic research and scientific papers

METHODS FOR MEASURING SMALL MOLECULE AFFINITY TO CEREBLON

A complex comprises a CRBN having a europium-anti-his antibody on the N-terminus of the CRBN, and a Cy5-conjugated small molecule, wherein the Cy5-conjugated small molecule binds the CRBN, and uses thereof for identifying therapeutic compounds.

A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos

The drugs lenalidomide and pomalidomide bind to the protein cereblon, directing the CRL4-CRBN E3 ligase toward the transcription factors Ikaros and Aiolos to cause their ubiquitination and degradation. Here we describe CC-220 (compound 6), a cereblon modu

3-(4-((4-(MORPHOLINOMETHYL-BENZYL)OXY)-1 -OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS

Provided herein are methods of using compounds and compositions for treating, managing, and/or preventing systemic lupus erythematosus (SLE). Pharmaceutical compositions and dosing regimens for use in the methods are also provided herein.

PROCESSES FOR THE PREPARATION OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE AND PHARMACEUTICALLY ACCEPTABLE FORMS THEREOF

Provided are processes for the preparation of enantiomerically enriched or enantiomerically pure 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a pharmaceutically acceptable form thereof.

SALTS AND SOLID FORMS OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME

Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a stereoisomer thereof, are disclosed. Compositions comprising and methos of using the salts and solid forms are also disclosed.

METHODS OF TREATING CANCER USING 3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE

Provided herein are methods of treating, preventing and/or managing cancers, which comprise administering to a patient 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof,

TREATMENT OF IMMUNE-RELATED AND INFLAMMATORY DISEASES

Provided herein are methods of using compounds and compositions for modulating leukocytic activity, including activity of B cells and/or T cells monocytes, macrophages, and other lymphoid or myeloid-derived cell types, in immune-related diseases or inflam

Arylmethoxy Isoindoline Derivatives and Compositions Comprising and Methods of Using the Same

Provided are 4′-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.