(4-isopropoxy-3-methoxybenzoyl)[4-isopropoxy-5-methoxy-2-((2-methoxyethoxy)methoxy)benzyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:(4-isopropoxy-3-methoxybenzoyl)[4-isopropoxy-5-methoxy-2-((2-methoxyethoxy)methoxy)benzyl]carbamic acid tert-butyl ester
CAS No.:1333109-50-4
Molecular Formula:C₃₁H₄₅NO₁₀
Molecular Weight:591.699
Hs Code.:

Synonyms:(4-isopropoxy-3-methoxybenzoyl)[4-isopropoxy-5-methoxy-2-((2-methoxyethoxy)methoxy)benzyl]carbamic acid tert-butyl ester

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Chemical Property of (4-isopropoxy-3-methoxybenzoyl)[4-isopropoxy-5-methoxy-2-((2-methoxyethoxy)methoxy)benzyl]carbamic acid tert-butyl ester

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Technology Process of (4-isopropoxy-3-methoxybenzoyl)[4-isopropoxy-5-methoxy-2-((2-methoxyethoxy)methoxy)benzyl]carbamic acid tert-butyl ester

There total 9 articles about (4-isopropoxy-3-methoxybenzoyl)[4-isopropoxy-5-methoxy-2-((2-methoxyethoxy)methoxy)benzyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1333109-49-1
4-isopropoxy-N-[4-isopropoxy-5-methoxy-2-((2-methoxyethoxy)methoxy)benzyl]-3-methoxybenzamide

: 1333109-50-4
(4-isopropoxy-3-methoxybenzoyl)[4-isopropoxy-5-methoxy-2-((2-methoxyethoxy)methoxy)benzyl]carbamic acid tert-butyl ester

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.06.056

Reference yield:

: 4-isopropoxy-3-methoxybenzoic acid isopropyl ester

: 1333109-50-4
(4-isopropoxy-3-methoxybenzoyl)[4-isopropoxy-5-methoxy-2-((2-methoxyethoxy)methoxy)benzyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol; water / 4 h / Reflux

1.2: pH 3

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

3.1: dmap / acetonitrile / 16 h / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1016/j.bmc.2011.06.056

Reference yield:

: 51061-83-7
2,4-dihydroxy-5-methoxybenzaldehyde

: 1333109-50-4
(4-isopropoxy-3-methoxybenzoyl)[4-isopropoxy-5-methoxy-2-((2-methoxyethoxy)methoxy)benzyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 70 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 12 h / 20 °C

3.1: pyridine; hydroxylamine hydrochloride / ethanol / 1.5 h / 20 °C

4.1: sodium hydroxide / ethanol / 1.5 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

6.1: dmap / acetonitrile / 16 h / 20 °C / Inert atmosphere

With pyridine; dmap; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.06.056