51061-83-7

Basic information

• Product Name: 2,4-DIHYDROXY-5-METHOXYBENZALDEHYDE
• Synonyms: 2,4-DIHYDROXY-5-METHOXYBENZALDEHYDE;2,4-dihydroxy-5-methoxybenzaldehyde(SALTDATA: FREE)
• CAS NO: 51061-83-7
• Molecular Formula: C₈H₈O₄
• Molecular Weight: 168.15
• Mol File: 51061-83-7.mol
• Article Data: 30

Chemical Properties

• Melting Point: 148-153°C
• Boiling Point: 350.7 °C at 760 mmHg
• Flash Point: 148.2 °C
• Appearance: /
• Density: 1.378 g/cm³
• Vapor Pressure: 2.13E-05mmHg at 25°C
• Refractive Index: 1.63
• PKA: 7.58±0.23(Predicted)
• CAS DataBase Reference: 2,4-DIHYDROXY-5-METHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIHYDROXY-5-METHOXYBENZALDEHYDE(51061-83-7)
• EPA Substance Registry System: 2,4-DIHYDROXY-5-METHOXYBENZALDEHYDE(51061-83-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 51061-83-7(Hazardous Substances Data)

Usage

General Description

2,4-Dihydroxy-5-methoxybenzaldehyde, also known as syringaldehyde, is a natural compound found in various plants and fruits. It is a derivative of the phenolic compound syringic acid, and is known for its antioxidant and antimicrobial properties. Syringaldehyde has been studied for its potential use in various industries, including food and pharmaceuticals, due to its ability to inhibit the growth of harmful microorganisms and its potential health benefits. It is also used in the production of fragrances and flavorings due to its pleasant aroma and taste. Additionally, syringaldehyde has been studied for its potential role in the treatment of conditions such as diabetes and cancer, as well as its ability to protect against oxidative damage in the body.

InChI:InChI=1/C8H8O4/c1-12-8-2-5(4-9)6(10)3-7(8)11/h2-4,10-11H,1H3

Upstream product

• 74-90-8 hydrogen cyanide 
• 6100-60-3 4-methoxybenzene-1,3-diol 
• 4460-86-0 asaraldehyde 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 135-77-3 1,2,4-trimethoxy-benzene 
• 3934-87-0 5-hydroxyvanillin 
• 1023595-24-5 4-formyl-5-iodo-2-methoxyphenyl-2,2-dimethylpropanoate 
• 246224-08-8 4-formyl-2-methoxyphenyl-2,2-dimethylpropanoate 
• 108-46-3 recorcinol 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 116096-90-3 5-bromo-2,4-dihydroxy-benzaldehyde 
• 124-41-4 sodium methylate 
• 7664-93-9 sulfuric acid 

Downstream Products

• 56795-51-8 7-acetoxy-6-methoxycoumarin 
• 92-61-5 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one 
• 4460-86-0 asaraldehyde 
• 73402-57-0 5-benzyloxy-2,2-dimethylchroman 
• 73402-58-1 (E)-3-(5-Benzyloxy-8-methoxy-2,2-dimethyl-chroman-6-yl)-1-(2-hydroxy-4,6-dimethoxy-phenyl)-propenone 
• 127861-47-6 3,7-dihydroxy-6-methoxycoumarin 
• 828933-87-5 2-hydroxy-5-methoxy-4-(2-trimethylsilanyl-ethoxy)-benzaldehyde 
• 141590-39-8 2-Hydroxy-5-methoxy-4-prenyloxybenzaldehyde 
• 103164-95-0 2-biphenyl-4-yl-3-(3,4-dimethoxy-phenyl)-6-methoxy-chromen-7-one 
• 121813-56-7 2-biphenyl-4-yl-3-(3,4-dimethoxy-phenyl)-7-hydroxy-6-methoxy-chromenylium; chloride 
• 119251-32-0 3-(3,4-dimethoxy-phenyl)-6-methoxy-2-(2,4,6-trimethoxy-phenyl)-chromen-7-one 
• 103161-66-6 2-biphenyl-4-yl-6-methoxy-3-phenyl-chromen-7-one 

Relevant articles and documents

Synthesis of 6-methoxy-4H-1-benzopyran-7-ol, a character donating component of the fragrance of Wisteria sinensis

6-Methoxy-4H-1-benzopyran-7-ol 7, a major impact flavor compound of Wisteria sinensis has been synthesized from 2,4,5-trimethoxybenzaldehyde 1 via scopoletin 3. The synthetic sequence comprised (i) bisdemethylation of 2,4,5-trimethoxybenzaldehyde 1, (ii) Wittig reaction with ethoxycarbonylmethylenetriphenylphosphorane, (iii) hydrogenation on palladium/carbon in glacial acetic acid, (iv) DIBAL-H reduction of the intermediate lactone and (v) dehydration of the lactol with anhydrous oxalic acid.

Coumarin derivative as well as synthesis method and application thereof

The invention belongs to the field of medicinal chemistry, and discloses a coumarin derivative shown as a formula I, wherein R1 is selected from H, a C1-C4 alkyl group and a C1-C4 alkoxy group, R2 isselected from substituted or unsubstituted phenyl, and a

Scopoletin benzene sulfonyl furazan oxynitride derivatives as well as preparation method and application thereof

The invention belongs to the field of biological medicines, and discloses scopoletin benzene sulfonyl furazan oxynitride derivatives as shown in a formula I, wherein R is selected from H, acetamido and amino, X is selected from -(CH2)n-, and n is an integer of 2-6. Compared with scopoletin, the derivatives have a stronger proliferation inhibition effect on MDA-MB-231, MCF-7, HepG2 and A549 cell strains, the proliferation inhibition effect on tumor cells is remarkably superior to that of scopoletin, and the derivatives are expected to become a new anti-tumor drug. The invention also discloses an application of the derivatives in the preparation of antitumor drugs.

Escoparone chemical whole synthetic method

The invention discloses escoparone chemical whole synthetic method, which belongs to the technical field of chemical synthesis, escoparone chemical full-synthetic method is 2, 4, 5 - trimethoxybenzaldehyde de-methyl generating 4 - dihydroxy - 5 - methoxybenzaldehyde; 4 - dihydroxy - 5 - methoxy benzaldehyde with malonic acid to generate the cyclization reaction to produce the 3 - carboxyl scopolamine lactone; 3 - carboxyl scopolamine lactone by microwave auxiliary decarboxylative generating scopolamine lactone; scopolamine lactone by methylation get escoparone, aims to solve the low efficiency of the plant extract, the disadvantage of low yield and the synthetic yield is low, high cost, is not suitable for the industrial application of the shortcomings.