3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

Base Information

Chemical Name:3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one
CAS No.:1574538-14-9
Molecular Formula:C₂₆H₃₂N₂O₄
Molecular Weight:436.551
Hs Code.:

Synonyms:3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

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Chemical Property of 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

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Technology Process of 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

There total 8 articles about 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 123-75-1
pyrrolidine

: 1574541-47-1
(R)-2-(4-(3-(4-cyclopropylphenoxy)-2-oxopyrrolidin-1-yl)-2-methoxyphenoxy)ethyl methanesulfonate

: 1574538-14-9
3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 80 ℃; for 12h;

Reference yield:

: 1574541-44-8
(±)-3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenyl)pyrrolidin-2-one

: 1574538-14-9
3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / dichloromethane; diethyl ether / 0 - 20 °C / Inert atmosphere

2: potassium carbonate; N-ethyl-N,N-diisopropylamine / 12 h / 80 °C

3: CHIRALCEL? OD-H column / ethanol; hexane; methanol / Resolution of racemate

4: triethylamine / dichloromethane / 6 h

5: potassium carbonate; potassium iodide / acetonitrile / 12 h / 80 °C

With hydrogenchloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; In methanol; diethyl ether; ethanol; hexane; dichloromethane; acetonitrile;

Reference yield:

: 1574541-45-9
(±)-3-(4-cyclopropylphenoxy)-1-(4-hydroxy-3-methoxyphenyl)pyrrolidin-2-one

: 1574538-14-9
3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; N-ethyl-N,N-diisopropylamine / 12 h / 80 °C

2: CHIRALCEL? OD-H column / ethanol; hexane; methanol / Resolution of racemate

3: triethylamine / dichloromethane / 6 h

4: potassium carbonate; potassium iodide / acetonitrile / 12 h / 80 °C

With potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; In methanol; ethanol; hexane; dichloromethane; acetonitrile;