(R)-N,N-dimethyl-2-(piperidin-3-yl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)acetamide

Base Information

Chemical Name:(R)-N,N-dimethyl-2-(piperidin-3-yl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)acetamide
CAS No.:1374242-15-5
Molecular Formula:C₂₂H₂₈N₆O₃S
Molecular Weight:456.569
Hs Code.:

Synonyms:(R)-N,N-dimethyl-2-(piperidin-3-yl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)acetamide

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Chemical Property of (R)-N,N-dimethyl-2-(piperidin-3-yl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)acetamide

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Technology Process of (R)-N,N-dimethyl-2-(piperidin-3-yl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)acetamide

There total 10 articles about (R)-N,N-dimethyl-2-(piperidin-3-yl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374242-14-4
(R)-benzyl 3-((2-(dimethylamino)-2-oxoethyl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

: 1374242-15-5
(R)-N,N-dimethyl-2-(piperidin-3-yl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)acetamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 2h; under 760.051 Torr;

Reference yield:

: 188111-79-7
tert-butyl (3R)3-aminopiperidine-1-carboxylate

: 1374242-15-5
(R)-N,N-dimethyl-2-(piperidin-3-yl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: hydrogenchloride; water / methanol / 0 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

5.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 0 °C

5.2: 0 - 20 °C

6.1: sodium periodate / dichloromethane / 0 - 20 °C

7.1: sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide / acetonitrile; water / 0 - 20 °C

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 - 20 °C

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 760.05 Torr

With hydrogenchloride; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; water; hydrogen; dihydrogen peroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1374242-00-8
(R)-tert-butyl 3-((7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

: 1374242-15-5
(R)-N,N-dimethyl-2-(piperidin-3-yl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; water / methanol / 0 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

4.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 0 °C

4.2: 0 - 20 °C

5.1: sodium periodate / dichloromethane / 0 - 20 °C

6.1: sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide / acetonitrile; water / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 - 20 °C

8.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 760.05 Torr

With hydrogenchloride; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; water; hydrogen; dihydrogen peroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;