(R)-benzyl 3-((2-(dimethylamino)-2-oxoethyl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

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Chemical Name:(R)-benzyl 3-((2-(dimethylamino)-2-oxoethyl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
CAS No.:1374242-14-4
Molecular Formula:C₃₀H₃₄N₆O₅S
Molecular Weight:590.703
Hs Code.:

Synonyms:(R)-benzyl 3-((2-(dimethylamino)-2-oxoethyl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

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Chemical Property of (R)-benzyl 3-((2-(dimethylamino)-2-oxoethyl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

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Technology Process of (R)-benzyl 3-((2-(dimethylamino)-2-oxoethyl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

There total 8 articles about (R)-benzyl 3-((2-(dimethylamino)-2-oxoethyl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1374242-13-3
(R)-2((1-(benzyloxycarbonyl)piperidine-3-yl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)acetic acid

: 124-40-3
dimethyl amine

: 1374242-14-4
(R)-benzyl 3-((2-(dimethylamino)-2-oxoethyl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1374242-08-6
(R)-benzyl 3-(allyl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

: 1374242-14-4
(R)-benzyl 3-((2-(dimethylamino)-2-oxoethyl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: sodium periodate / dichloromethane / 0 - 20 °C

3.1: sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide / acetonitrile; water / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 - 20 °C

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; water; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 1391755-91-1
(3R)-benzyl 3-((2,3-dihydroxypropyl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

: 1374242-14-4
(R)-benzyl 3-((2-(dimethylamino)-2-oxoethyl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium periodate / dichloromethane / 0 - 20 °C

2: sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide / acetonitrile; water / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 - 20 °C

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetonitrile;