{(S)-4-Guanidino-1-[2-({[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-4-phenoxymethyl-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{(S)-4-Guanidino-1-[2-({[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-4-phenoxymethyl-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester
CAS No.:157487-69-9
Molecular Formula:C₃₃H₄₇N₁₁O₉
Molecular Weight:741.804
Hs Code.:

{(S)-4-Guanidino-1-[2-({[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-4-phenoxymethyl-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester

Synonyms:{(S)-4-Guanidino-1-[2-({[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-4-phenoxymethyl-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester

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Chemical Property of {(S)-4-Guanidino-1-[2-({[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-4-phenoxymethyl-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester

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Technology Process of {(S)-4-Guanidino-1-[2-({[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-4-phenoxymethyl-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester

There total 9 articles about {(S)-4-Guanidino-1-[2-({[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-4-phenoxymethyl-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 157487-66-6
[2-(2-{2-[2-((S)-2-tert-Butoxycarbonylamino-5-guanidino-pentanoylamino)-5-phenoxymethyl-benzoylamino]-acetylamino}-acetylamino)-acetylamino]-acetic acid ethyl ester

: 157487-69-9
{(S)-4-Guanidino-1-[2-({[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-4-phenoxymethyl-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: With hydrazine hydrate; In methanol; for 0.05h; Ambient temperature;

Reference yield:

: 3113-72-2
5-methyl-2-nitrobenzoic acid

: 157487-69-9
{(S)-4-Guanidino-1-[2-({[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-4-phenoxymethyl-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 32.6 g / AcCl / Heating

2: NBS, benzoyl-peroxide / CCl₄ / Heating

3: aq. NaOH, aliquat / CH₂Cl₂ / 5 h / Ambient temperature

4: 85 percent / aq. 4N KOH / methanol / 2 h / Ambient temperature

5: SOCl₂, DMF / 2 h / Ambient temperature

6: 89 percent / Et₃N / dimethylformamide / 1.) 0 deg C, 2 h; 2.) r.t.

7: H₂ / PtO₂ / methanol; dimethylformamide / 2 h / Ambient temperature

8: 27 percent / pyridine, 3.8N HCl in ether, DCC / diethyl ether; dimethylformamide / 1.) from -10 deg C to 0 deg C, 2 h; 2.) r.t., 3 d

9: 100 percent / NH₂NH₂*H₂O / methanol / 0.05 h / Ambient temperature

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; Aliquat; hydrogen; hydrazine hydrate; triethylamine; acetyl chloride; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; platinum(IV) oxide; In methanol; tetrachloromethane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 20587-30-8
5-methyl-2-nitro-benzoic acid methyl ester

: 157487-69-9
{(S)-4-Guanidino-1-[2-({[({[(hydrazinocarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-4-phenoxymethyl-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: NBS, benzoyl-peroxide / CCl₄ / Heating

2: aq. NaOH, aliquat / CH₂Cl₂ / 5 h / Ambient temperature

3: 85 percent / aq. 4N KOH / methanol / 2 h / Ambient temperature

4: SOCl₂, DMF / 2 h / Ambient temperature

5: 89 percent / Et₃N / dimethylformamide / 1.) 0 deg C, 2 h; 2.) r.t.

6: H₂ / PtO₂ / methanol; dimethylformamide / 2 h / Ambient temperature

7: 27 percent / pyridine, 3.8N HCl in ether, DCC / diethyl ether; dimethylformamide / 1.) from -10 deg C to 0 deg C, 2 h; 2.) r.t., 3 d

8: 100 percent / NH₂NH₂*H₂O / methanol / 0.05 h / Ambient temperature

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; Aliquat; hydrogen; hydrazine hydrate; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; platinum(IV) oxide; In methanol; tetrachloromethane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;