4,4,4-trifluoro-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)butane-1,3-dione

Base Information

• Chemical Name: 4,4,4-trifluoro-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)butane-1,3-dione
• CAS No.: 943994-23-8
• Molecular Formula: C₁₂H₈F₃NO₄
• Molecular Weight: 287.195

Synonyms:4,4,4-trifluoro-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)butane-1,3-dione

Chemical Property of 4,4,4-trifluoro-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)butane-1,3-dione

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

4,4,4-Trifluoro-1-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)butane-1,3-dione ^*data from reagent suppliers

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Technology Process of 4,4,4-trifluoro-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)butane-1,3-dione

There total 2 articles about 4,4,4-trifluoro-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)butane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-acetyl-4H-benzo[1,4]oxazin-3-one (26518-71-8) → 4,4,4-trifluoro-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)butane-1,3-dione (943994-23-8)

Guidance literature:

ethyl trifluoroacetate,; With sodium hydride; In tetrahydrofuran;

6-acetyl-4H-benzo[1,4]oxazin-3-one; With dibenzo-18-crown-6; In tetrahydrofuran; ethanol; for 16h; Heating / reflux;

Reference yield: 80.0%

ethyl trifluoroacetate, (383-63-1) + 6-acetyl-4H-benzo[1,4]oxazin-3-one (26518-71-8) → 4,4,4-trifluoro-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)butane-1,3-dione (943994-23-8)

Guidance literature:

With 6,7,9,10,12,13,20,21-octahydrodibenzo[b,h][1,4,7,10,13,16]hexaoxacyclooctadecine; sodium hydride; In tetrahydrofuran; ethanol; for 16h; Reflux;

DOI:10.1021/jm2011645

Reference yield: 86.0%

4,4,4-trifluoro-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)butane-1,3-dione (943994-23-8) + 3-fluorophenylhydrazine hydrochloride (2924-16-5,50702-51-7) → 6-[1-(3-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:

With triethylamine; trifluoroacetic acid; In isopropyl alcohol; at 60 ℃; for 12h;

DOI:10.1021/jm2011645

upstream raw materials:

6-acetyl-4H-benzo[1,4]oxazin-3-one

ethyl trifluoroacetate,

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