2-{4-[(1-aminocyclopropyl)methyl]-2-methylphenyl}-4,9-diethoxy-2,3-dihydro-1H-benzo[f]isoindol-1-one

Base Information

Chemical Name:2-{4-[(1-aminocyclopropyl)methyl]-2-methylphenyl}-4,9-diethoxy-2,3-dihydro-1H-benzo[f]isoindol-1-one
CAS No.:1064195-77-2
Molecular Formula:C₂₇H₃₀N₂O₃
Molecular Weight:430.547
Hs Code.:

Synonyms:2-{4-[(1-aminocyclopropyl)methyl]-2-methylphenyl}-4,9-diethoxy-2,3-dihydro-1H-benzo[f]isoindol-1-one

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Chemical Property of 2-{4-[(1-aminocyclopropyl)methyl]-2-methylphenyl}-4,9-diethoxy-2,3-dihydro-1H-benzo[f]isoindol-1-one

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Technology Process of 2-{4-[(1-aminocyclopropyl)methyl]-2-methylphenyl}-4,9-diethoxy-2,3-dihydro-1H-benzo[f]isoindol-1-one

There total 12 articles about 2-{4-[(1-aminocyclopropyl)methyl]-2-methylphenyl}-4,9-diethoxy-2,3-dihydro-1H-benzo[f]isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1064195-76-1
[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylphenyl]acetonitrile

: 925-90-6
ethylmagnesium bromide

: 1064195-77-2
2-{4-[(1-aminocyclopropyl)methyl]-2-methylphenyl}-4,9-diethoxy-2,3-dihydro-1H-benzo[f]isoindol-1-one

Guidance literature:: [4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylphenyl]acetonitrile; ethylmagnesium bromide; With titanium(IV) isopropylate; In tetrahydrofuran;

With boron trifluoride diethyl etherate;
DOI:10.1016/j.bmcl.2010.12.014

Reference yield:

: 1064195-70-5
methyl 4-(4,9-diethoxy-1-hydroxy-3-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoate

: 1064195-77-2
2-{4-[(1-aminocyclopropyl)methyl]-2-methylphenyl}-4,9-diethoxy-2,3-dihydro-1H-benzo[f]isoindol-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: triethylsilane; trifluoroacetic acid / dichloromethane

2: water; lithium hydroxide / tetrahydrofuran; methanol

3: dimethylsulfide borane complex / tetrahydrofuran

4: triethylamine / dichloromethane

5: N,N-dimethyl-formamide

6: titanium(IV) isopropylate / tetrahydrofuran

With titanium(IV) isopropylate; triethylsilane; dimethylsulfide borane complex; water; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 6: Kulinkovich reaction / 6: Kulinkovich reaction;
DOI:10.1016/j.bmcl.2010.12.014

Reference yield:

: 1064195-71-6
methyl 4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoate

: 1064195-77-2
2-{4-[(1-aminocyclopropyl)methyl]-2-methylphenyl}-4,9-diethoxy-2,3-dihydro-1H-benzo[f]isoindol-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol

2: dimethylsulfide borane complex / tetrahydrofuran

3: triethylamine / dichloromethane

4: N,N-dimethyl-formamide

5: titanium(IV) isopropylate / tetrahydrofuran

With titanium(IV) isopropylate; dimethylsulfide borane complex; water; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 5: Kulinkovich reaction / 5: Kulinkovich reaction;
DOI:10.1016/j.bmcl.2010.12.014