N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]-2-(trifluoromethyl)benzenesulfonamide

Base Information

Chemical Name:N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]-2-(trifluoromethyl)benzenesulfonamide
CAS No.:1064195-55-6
Molecular Formula:C₃₅H₃₄F₃N₃O₆S
Molecular Weight:681.733
Hs Code.:

N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]-2-(trifluoromethyl)benzenesulfonamide

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Chemical Property of N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]-2-(trifluoromethyl)benzenesulfonamide

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Technology Process of N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]-2-(trifluoromethyl)benzenesulfonamide

There total 10 articles about N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]-2-(trifluoromethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 325780-77-6
4,9-bis(ethyloxy)naphtho[2,3-c]furan-1,3-dione

: 1064195-55-6
N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]-2-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: acetic acid / Reflux

2: sodium tetrahydroborate / tetrahydrofuran; methanol

3: triethylsilane; trifluoroacetic acid / dichloromethane

4: water; lithium hydroxide / tetrahydrofuran; methanol

5: dimethylsulfide borane complex / tetrahydrofuran

6: triethylamine / dichloromethane

7: N,N-dimethyl-formamide

8: titanium(IV) isopropylate / tetrahydrofuran

9: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

With titanium(IV) isopropylate; triethylsilane; sodium tetrahydroborate; dimethylsulfide borane complex; water; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 8: Kulinkovich reaction / 8: Kulinkovich reaction;
DOI:10.1016/j.bmcl.2010.12.014

Reference yield:

: 1064195-69-2
methyl 4-(4,9-diethoxy-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoate

: 1064195-55-6
N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]-2-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol

2: triethylsilane; trifluoroacetic acid / dichloromethane

3: water; lithium hydroxide / tetrahydrofuran; methanol

4: dimethylsulfide borane complex / tetrahydrofuran

5: triethylamine / dichloromethane

6: N,N-dimethyl-formamide

7: titanium(IV) isopropylate / tetrahydrofuran

8: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

With titanium(IV) isopropylate; triethylsilane; sodium tetrahydroborate; dimethylsulfide borane complex; water; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 7: Kulinkovich reaction / 7: Kulinkovich reaction;
DOI:10.1016/j.bmcl.2010.12.014

Reference yield:

: 1064195-70-5
methyl 4-(4,9-diethoxy-1-hydroxy-3-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzoate

: 1064195-55-6
N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]-2-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylsilane; trifluoroacetic acid / dichloromethane

2: water; lithium hydroxide / tetrahydrofuran; methanol

3: dimethylsulfide borane complex / tetrahydrofuran

4: triethylamine / dichloromethane

5: N,N-dimethyl-formamide

6: titanium(IV) isopropylate / tetrahydrofuran

7: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

With titanium(IV) isopropylate; triethylsilane; dimethylsulfide borane complex; water; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 6: Kulinkovich reaction / 6: Kulinkovich reaction;
DOI:10.1016/j.bmcl.2010.12.014