2-[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-phenyl]sulfanyl-N-(2,2,2-trifluoroethyl)acetamide

Base Information

Chemical Name:2-[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-phenyl]sulfanyl-N-(2,2,2-trifluoroethyl)acetamide
CAS No.:1413283-75-6
Molecular Formula:C₂₁H₁₆Cl₂F₆N₂O₂S
Molecular Weight:545.333
Hs Code.:

Synonyms:2-[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-phenyl]sulfanyl-N-(2,2,2-trifluoroethyl)acetamide

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Chemical Property of 2-[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-phenyl]sulfanyl-N-(2,2,2-trifluoroethyl)acetamide

Chemical Property:

Purity/Quality:

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Technology Process of 2-[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-phenyl]sulfanyl-N-(2,2,2-trifluoroethyl)acetamide

There total 10 articles about 2-[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-phenyl]sulfanyl-N-(2,2,2-trifluoroethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 753-90-2
trifluoroethylamine

: 1413285-50-3
{4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylphenylsulfanyl}acetic acid

: 1413283-75-6
2-[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-phenyl]sulfanyl-N-(2,2,2-trifluoroethyl)acetamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In acetonitrile; at 20 ℃; Inert atmosphere;

Reference yield:

: 180082-96-6
4-bromo-3-methylbenzaldehyde oxime

: 1413283-75-6
2-[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-phenyl]sulfanyl-N-(2,2,2-trifluoroethyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 28 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 20 °C / Inert atmosphere

With N-chloro-succinimide; 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 5-(3,5-dichloro-phenyl)-3-(4-bromo-3-methyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

: 1413283-75-6
2-[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-phenyl]sulfanyl-N-(2,2,2-trifluoroethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 20 °C / Inert atmosphere

With 1-hydroxy-7-aza-benzotriazole; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; acetonitrile;