Technology Process of (S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid
There total 9 articles about (S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid methyl ester;
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
for 4h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - -65 °C / Inert atmosphere
1.2: 0.33 h / Saturated solution
2.1: n-butyllithium / tetrahydrofuran; n-heptane / 0.25 h / -78 °C
2.2: 0.5 h / -78 °C / Inert atmosphere
2.3: 1.5 h / -78 °C
3.1: potassium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 20 h / 110 °C / Inert atmosphere
4.1: sulfuryl dichloride; water; acetic acid / dichloromethane / 1.58 h / 0 - 20 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h
With
n-butyllithium; sulfuryl dichloride; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; lithium diisopropyl amide;
copper(l) iodide; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; methanol; n-heptane; dichloromethane; ethylbenzene; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; n-heptane / 0.25 h / -78 °C
1.2: 0.5 h / -78 °C / Inert atmosphere
1.3: 1.5 h / -78 °C
2.1: potassium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 20 h / 110 °C / Inert atmosphere
3.1: sulfuryl dichloride; water; acetic acid / dichloromethane / 1.58 h / 0 - 20 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h
With
n-butyllithium; sulfuryl dichloride; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
copper(l) iodide; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; methanol; n-heptane; dichloromethane; toluene;
![(S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-propionic acid methyl ester](/Databaselist/images/loading.webp)
