Multi-step reaction with 7 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - -65 °C / Inert atmosphere
1.2: 0.33 h / Saturated solution
2.1: n-butyllithium / tetrahydrofuran; n-heptane / 0.25 h / -78 °C
2.2: 0.5 h / -78 °C / Inert atmosphere
2.3: 1.5 h / -78 °C
3.1: potassium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 20 h / 110 °C / Inert atmosphere
4.1: sulfuryl dichloride; water; acetic acid / dichloromethane / 1.58 h / 0 - 20 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h
7.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide
With
n-butyllithium; sulfuryl dichloride; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; lithium diisopropyl amide;
copper(l) iodide; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; methanol; n-heptane; dichloromethane; ethylbenzene; N,N-dimethyl-formamide; toluene;