Technology Process of 1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-3-(3-(4-phenylpiperidin-1-yl)propyl)pyrrolidin-2-one trifluoroacetate
There total 9 articles about 1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-3-(3-(4-phenylpiperidin-1-yl)propyl)pyrrolidin-2-one trifluoroacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-phenylpiperidine; 3-(1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-2-oxopyrrolidin-3-yl)propanal;
With
sodium tris(acetoxy)borohydride;
In
dichloromethane;
for 3h;
4 ? Molecular Sieves;
trifluoroacetic acid;
In
methanol; water;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 - -15 °C
1.2: 3 h / -78 - -70 °C
2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 - -20 °C
2.2: -78 - 20 °C
3.1: triphenylphosphine; ozone / dichloromethane / -78 - 20 °C
4.1: sodium tetrahydroborate / methanol / 0 - 20 °C
5.1: lithium hydroxide; methanol / water; tetrahydrofuran / 4 h / 20 °C
6.1: hydrogen / Lindlar catalyst / methanol / 2 h
7.1: borane-THF / tetrahydrofuran / 14 h / 0 - 20 °C
7.2: 2 h
8.1: 4-methyl-morpholine / tetrapropylammonium perruthennate / dichloromethane / 0.5 h / 4 ? Molecular sieve
9.1: sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 4 ? Molecular Sieves
9.2: Waters Sunfire C18
With
4-methyl-morpholine; methanol; sodium tetrahydroborate; n-butyllithium; borane-THF; hydrogen; sodium tris(acetoxy)borohydride; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide;
tetrapropylammonium perruthennate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate / methanol / 0 - 20 °C
2.1: lithium hydroxide; methanol / water; tetrahydrofuran / 4 h / 20 °C
3.1: hydrogen / Lindlar catalyst / methanol / 2 h
4.1: borane-THF / tetrahydrofuran / 14 h / 0 - 20 °C
4.2: 2 h
5.1: 4-methyl-morpholine / tetrapropylammonium perruthennate / dichloromethane / 0.5 h / 4 ? Molecular sieve
6.1: sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 4 ? Molecular Sieves
6.2: Waters Sunfire C18
With
4-methyl-morpholine; methanol; sodium tetrahydroborate; borane-THF; hydrogen; sodium tris(acetoxy)borohydride; lithium hydroxide;
tetrapropylammonium perruthennate;
In
tetrahydrofuran; methanol; dichloromethane; water;
