C₂₀H₂₂INO₃

Base Information

• Chemical Name: C₂₀H₂₂INO₃
• CAS No.: 1320362-81-9
• Molecular Formula: C₂₀H₂₂INO₃
• Molecular Weight: 451.304
• Mol file: 1320362-81-9.mol

Synonyms:C₂₀H₂₂INO₃

Chemical Property of C₂₀H₂₂INO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₂INO₃

There total 3 articles about C₂₀H₂₂INO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + C19H19NO2 (1320362-87-5) → C20H22INO3 (1320362-81-9)

Guidance literature:

With iodine; potassium carbonate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/co200100z

Reference yield:

2-chloro-6-methoxyquinolin-3-carboxaldehyde (73568-29-3) → C20H22INO3 (1320362-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trans-bis(triphenylphosphine)palladium dichloride; triethylamine / 60 °C

2: iodine; potassium carbonate / dichloromethane / 2 h / 20 °C

With trans-bis(triphenylphosphine)palladium dichloride; iodine; potassium carbonate; triethylamine; In dichloromethane; 1: Sonogashira coupling;

DOI:10.1021/co200100z

Reference yield:

2-cyclohexylacetylene (931-48-6) → C20H22INO3 (1320362-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trans-bis(triphenylphosphine)palladium dichloride; triethylamine / 60 °C

2: iodine; potassium carbonate / dichloromethane / 2 h / 20 °C

With trans-bis(triphenylphosphine)palladium dichloride; iodine; potassium carbonate; triethylamine; In dichloromethane; 1: Sonogashira coupling;

DOI:10.1021/co200100z

upstream raw materials:

methanol

C₁₉H₁₉NO₂

2-chloro-6-methoxyquinolin-3-carboxaldehyde

2-cyclohexylacetylene