1-(4-(p-Tolyloxy)phenyl)ethanone

Base Information

• Chemical Name: 1-(4-(p-Tolyloxy)phenyl)ethanone
• CAS No.: 71815-31-1
• Molecular Formula: C15H14 O2
• Molecular Weight: 226.275
• European Community (EC) Number: 658-324-9
• Nikkaji Number: J1.737.893G
• Mol file: 71815-31-1.mol

Synonyms:1-(4-(p-tolyloxy)phenyl)ethanone;71815-31-1;1-[4-(4-methylphenoxy)phenyl]ethanone;1-[4-(4-Methylphenoxy)phenyl]-ethanone;1-(4-(4-METHYLPHENOXY)PHENYL)ETHANONE;SCHEMBL903435;AKOS000219364;AB92062;A50608

Chemical Property of 1-(4-(p-Tolyloxy)phenyl)ethanone

Chemical Property:

• PSA: 26.30000
• LogP: 3.98990
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 226.099379685
• Heavy Atom Count: 17
• Complexity: 246

Purity/Quality:

97% ^*data from raw suppliers

1-(4-(P-TOLYLOXY)PHENYL)ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)OC2=CC=C(C=C2)C(=O)C

Technology Process of 1-(4-(p-Tolyloxy)phenyl)ethanone

There total 15 articles about 1-(4-(p-Tolyloxy)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-cresol (106-44-5) + para-bromoacetophenone (99-90-1) → 4-(p-tolyloxy)acetophenone (71815-31-1)

Guidance literature:

With potassium phosphate; 2-((o-toluidino)methyl)phenol; copper(l) chloride; In acetonitrile; at 81 ℃; for 24h; Catalytic behavior; Schlenk technique; Inert atmosphere;

DOI:10.5012/bkcs.2013.34.12.3915

Reference yield: 94.0%

p-cresol (106-44-5) + 4-Iodoacetophenone (13329-40-3) → 4-(p-tolyloxy)acetophenone (71815-31-1)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In dihexyl ether; dimethyl sulfoxide; at 130 ℃; for 12h; Open air atmosphere;

DOI:10.1007/s11243-010-9426-2

Reference yield: 86.0%

p-cresol (106-44-5) + (4-nitrophenyl)ethanone (100-19-6) → 4-(p-tolyloxy)acetophenone (71815-31-1)

Guidance literature:

With copper(II) acetate monohydrate; caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2012.08.032

upstream raw materials:

potassium p-cresolate

para-bromoacetophenone

4-phenoxytoluene

acetyl chloride

Downstream raw materials:

3-Dimethylamino-2-dimethylaminomethyl-1-(4-p-tolyloxy-phenyl)-propan-1-one; hydrochloride

4-methylphenyl 4-(hydroxyisopropyl)phenyl ether

4-methylphenyl 4-(chloroisopropyl)phenyl ether