(R)-phenyl-2-(6-bromo-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate

Base Information

Chemical Name:(R)-phenyl-2-(6-bromo-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate
CAS No.:1577989-36-6
Molecular Formula:C₂₅H₂₀BrF₃N₂O₄
Molecular Weight:549.344
Hs Code.:

Synonyms:(R)-phenyl-2-(6-bromo-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate

Suppliers and Price of (R)-phenyl-2-(6-bromo-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-phenyl-2-(6-bromo-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-phenyl-2-(6-bromo-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate

There total 1 articles about (R)-phenyl-2-(6-bromo-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 35756-54-8
malonic acid monophenyl ester

: 1360590-84-6
C₁₇H₁₂BrF₃N₂O₂

: 1577989-36-6
(R)-phenyl-2-(6-bromo-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate

Guidance literature:: With C₂₅H₃₉N₃O₉S; In tetrahydrofuran; at 25 ℃; enantioselective reaction; Schlenk technique;
DOI:10.1002/chem.201303307

Reference yield: 81.0%

: 1577989-36-6
(R)-phenyl-2-(6-bromo-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate

: 1577989-85-5
(R)-6-bromo-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Guidance literature:: With sodium tetrahydroborate; calcium chloride; In methanol; at 0 ℃;
DOI:10.1002/chem.201303307

Reference yield:

: 1577989-36-6
(R)-phenyl-2-(6-bromo-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate

: 1577989-89-9
(R)-8-bromo-5-(4-methoxybenzyl)-9b-(trifluoromethyl)-5,9b-dihydro-1H-azeto[1,2-c]quinazolin-4(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; calcium chloride / methanol / 0 °C

2: potassium hydroxide; p-toluenesulfonyl chloride / tetrahydrofuran / 4 h / Reflux

With sodium tetrahydroborate; p-toluenesulfonyl chloride; calcium chloride; potassium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1002/chem.201303307