4-chloro-1H-pyrrolo[2,3-b]pyridine-7-oxide 3-chlorobenzoic acid salt

Base Information

• Chemical Name: 4-chloro-1H-pyrrolo[2,3-b]pyridine-7-oxide 3-chlorobenzoic acid salt
• CAS No.: 935466-76-5
• Molecular Formula: C₇H₅ClN₂O*C₇H₅ClO₂
• Molecular Weight: 325.151
• Mol file: 935466-76-5.mol

Synonyms:4-chloro-1H-pyrrolo[2,3-b]pyridine-7-oxide 3-chlorobenzoic acid salt

Chemical Property of 4-chloro-1H-pyrrolo[2,3-b]pyridine-7-oxide 3-chlorobenzoic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-1H-pyrrolo[2,3-b]pyridine-7-oxide 3-chlorobenzoic acid salt

There total 2 articles about 4-chloro-1H-pyrrolo[2,3-b]pyridine-7-oxide 3-chlorobenzoic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-chloro-benzenecarboperoxoic acid (937-14-4) + 4-chloro-7-azaindole (55052-28-3) → 4-chloro-1H-pyrrolo[2,3-b]pyridine-7-oxide 3-chlorobenzoic acid salt (935466-76-5)

Guidance literature:

In ethyl acetate; at 0 ℃; for 2h;

Reference yield: 88.0%

3-chlorobenzoate (535-80-8) + 4-chloro-7-azaindole (55052-28-3) → 4-chloro-1H-pyrrolo[2,3-b]pyridine-7-oxide 3-chlorobenzoic acid salt (935466-76-5)

Guidance literature:

In n-heptane;

DOI:10.1055/s-2007-1000853

Reference yield:

4-chloro-1H-pyrrolo[2,3-b]pyridine-7-oxide 3-chlorobenzoic acid salt (935466-76-5) → N-(4-(4-(2-cyanoacetyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)cyclopropanecarboxamide

Guidance literature:

Multi-step reaction with 5 steps

1.1: dimethyl sulfate / acetonitrile / 12 h / 55 °C

1.2: 72 h / 0 - 45 °C

2.1: pyridine / 1 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.1: palladium diacetate; CyJohnPhos; potassium acetate / 1,4-dioxane / 2 h / 100 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide; water / 2 h / 100 - 110 °C

5.2: 4 h / 30 - 40 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; palladium diacetate; sodium hydride; potassium carbonate; dimethyl sulfate; CyJohnPhos; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

3-chlorobenzoate

4-chloro-7-azaindole

3-chloro-benzenecarboperoxoic acid