Technology Process of (2E,6E)-4-methoxymethoxy-3-(3,7,11-trimethyldodeca-2,6,10-trienyl)benzaldehyde
There total 9 articles about (2E,6E)-4-methoxymethoxy-3-(3,7,11-trimethyldodeca-2,6,10-trienyl)benzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-[3-bromo-4-(methoxymethoxy)phenyl]-1,3-dioxolane;
With
n-butyllithium;
In
diethyl ether; hexane; toluene;
at 25 ℃;
for 0.0833333h;
Molecular sieve;
Inert atmosphere;
With
copper(I) bromide dimethylsulfide complex;
In
diethyl ether; hexane; toluene;
for 0.5h;
Molecular sieve;
Inert atmosphere;
farnesyl bromide;
In
diethyl ether; hexane; toluene;
for 4h;
Molecular sieve;
Inert atmosphere;
DOI:10.1039/c3md00236e
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C
2.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C
3.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran / 1 h / -30 °C
4.2: 20 h / -30 - 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h
With
1H-imidazole; sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
6.1: Swern oxidation;
DOI:10.1016/j.cclet.2011.05.010
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
2: Swern oxidation;
DOI:10.1016/j.cclet.2011.05.010
![2-[3-bromo-4-(methoxymethoxy)phenyl]-1,3-dioxolane](/Databaselist/images/loading.webp)
