di-tert-butyl 2-bromoisophthalate

Base Information

• Chemical Name: di-tert-butyl 2-bromoisophthalate
• CAS No.: 1253189-33-1
• Molecular Formula: C₁₆H₂₁BrO₄
• Molecular Weight: 357.244
• Mol file: 1253189-33-1.mol

Synonyms:di-tert-butyl 2-bromoisophthalate

Chemical Property of di-tert-butyl 2-bromoisophthalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl 2-bromoisophthalate

There total 1 articles about di-tert-butyl 2-bromoisophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-bromoisophthalic acid (22433-91-6) + tert-butyl alcohol (75-65-0) → di-tert-butyl 2-bromoisophthalate (1253189-33-1)

Guidance literature:

With sulfuric acid; magnesium sulfate; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1246/bcsj.20090342

Reference yield: 91.0%

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) + di-tert-butyl 2-bromoisophthalate (1253189-33-1) → di-t-butyl 2-(4,4,5,5-tetramethyl-1,3,2-di-oxaborolan-2-yl)isophthalate*2-hydroxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1253189-40-0)

Guidance literature:

di-tert-butyl 2-bromoisophthalate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1246/bcsj.20090342

Reference yield: 44.0%

di-tert-butyl 2-bromoisophthalate (1253189-33-1) + 9-chloro-9-borafluorene (13059-59-1) → di-t-butyl 2-(5H-dibenzoborol-5-yl)isophthalate

Guidance literature:

di-tert-butyl 2-bromoisophthalate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

9-chloro-9-borafluorene; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1246/bcsj.20090342

upstream raw materials:

2-bromoisophthalic acid

tert-butyl alcohol

Downstream raw materials:

di-t-butyl 2-(4,4,5,5-tetramethyl-1,3,2-di-oxaborolan-2-yl)isophthalate*2-hydroxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane