(1S,5R)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol

Base Information

Chemical Name:(1S,5R)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
CAS No.:22932-25-8
Molecular Formula:C14H19 N O
Molecular Weight:217.30676
Hs Code.:2933990090
DSSTox Substance ID:DTXSID60474506
Nikkaji Number:J132.947B
NSC Number:363965
Wikidata:Q82304558
Mol file:22932-25-8.mol

Synonyms:22932-25-8;NSC363965;DTXSID60474506;NSC-363965

Suppliers and Price of (1S,5R)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(1R,3R,5S)-8-METHYL-3-PHENYL-8-AZABICYCLO[3.2.1]OCTAN-3-OL 95.00%
5MG
$ 505.62

Total 4 raw suppliers

Chemical Property of (1S,5R)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol

Chemical Property:

Vapor Pressure:1.06E-05mmHg at 25°C
Boiling Point:356.5°C at 760 mmHg
Flash Point:135.3°C
PSA：23.47000
Density:1.122g/cm³
LogP:2.06870
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:217.146664230
Heavy Atom Count:16
Complexity:246

Purity/Quality:

99% ^*data from raw suppliers

(1R,3R,5S)-8-METHYL-3-PHENYL-8-AZABICYCLO[3.2.1]OCTAN-3-OL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2CCC1CC(C2)(C3=CC=CC=C3)O
Isomeric SMILES:CN1[C@@H]2CC[C@H]1CC(C2)(C3=CC=CC=C3)O

Technology Process of (1S,5R)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol

There total 2 articles about (1S,5R)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 532-24-1
tropinone

: 591-51-5
phenyllithium

: 22932-25-8
3-phenyltropine

Guidance literature:: With diethyl ether;
DOI:10.1021/ja01151a124

Reference yield:

: 532-24-1
tropan-3-one

: 591-51-5
phenyllithium

: 22932-25-8,23869-15-0
(1S,5R,8S)-8-Methyl-3-phenyl-8-aza-bicyclo[3.2.1]octan-3-ol

Guidance literature:: In diethyl ether; 1.) overnight, 2.) reflux, 1 h;
DOI:10.1111/j.2042-7158.1992.tb03206.x

Reference yield: 40.0%

: 22932-25-8
3-phenyltropine

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 8-methyl-3-(4-nitrophenoxy)-3-phenyl-8-azabicyclo[3.2.1]octane

Guidance literature:: 3-phenyltropine; With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

4-Fluoronitrobenzene; In N,N-dimethyl-formamide; at -70 ℃; for 2h; Further stages.;
DOI:10.1016/j.bmc.2007.08.055