(1R,5S)-8-Methyl-3-phenyl-8-azabicyclo[3.2.1]oct-2-ene

Base Information

• Chemical Name: (1R,5S)-8-Methyl-3-phenyl-8-azabicyclo[3.2.1]oct-2-ene
• CAS No.: 17814-96-9
• Molecular Formula: C₁₄H₁₇N
• Molecular Weight: 199.296
• Mol file: 17814-96-9.mol

Synonyms:3-Phenyl-tropidin;8-methyl-3-phenyl-nortrop-2-ene;2-Phenyltropidin;(1R,5S)-8-Methyl-3-phenyl-8-azabicyclo[3.2.1]oct-2-ene;8-methyl-3-phenyl-8-azabicyclo[3.2.1]oct-2-ene;3-Phenyl-trop-2-en;3-phenyl-trop-2-ene;(1R,5S)-2,3-Didehydro-3-phenyltropane;

Chemical Property of (1R,5S)-8-Methyl-3-phenyl-8-azabicyclo[3.2.1]oct-2-ene

Chemical Property:

• Vapor Pressure: 0.000846mmHg at 25°C
• Boiling Point: 305°C at 760 mmHg
• Flash Point: 126°C
• PSA: 3.24000
• Density: 1.051g/cm³
• LogP: 2.87440

Purity/Quality:

90%,98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,5S)-8-Methyl-3-phenyl-8-azabicyclo[3.2.1]oct-2-ene

There total 5 articles about (1R,5S)-8-Methyl-3-phenyl-8-azabicyclo[3.2.1]oct-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-hydroxy-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane (23869-15-0) → 8-methyl-3-phenyl-nortrop-2-ene (17814-96-9,50894-95-6,50894-96-7)

Guidance literature:

With hydrogen bromide; at 75 ℃;

DOI:10.1016/S0960-894X(03)00261-0

Reference yield:

tropinone (532-24-1) → 8-methyl-3-phenyl-nortrop-2-ene (17814-96-9,50894-95-6,50894-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 24 percent / diethyl ether / 0 - 20 °C

2: 100 percent / 48 percent HBr / 75 °C

With hydrogen bromide; In diethyl ether;

DOI:10.1016/S0960-894X(03)00261-0

Reference yield:

3-phenyltropine (22932-25-8) → 8-methyl-3-phenyl-nortrop-2-ene (17814-96-9,50894-95-6,50894-96-7)

Guidance literature:

With potassium hydroxide; thionyl chloride; diethyl ether;

DOI:10.1021/ja01151a124

upstream raw materials:

3-phenyltropine

3-hydroxy-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane

tropinone

phenyllithium

Downstream raw materials:

3α-Phenyl-tropan

[4-phenyl-1-(3-phenyl-8-aza-bicyclo[3.2.1]octane-8-carbonyl)-butyl]-carbamic acid tert-butyl ester

[1-(1H-indol-3-ylmethyl)-2-oxo-2-(3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-ethyl]-carbamic acid tert-butyl ester

{1-methyl-1-[4-phenyl-1-(3-phenyl-8-aza-bicyclo[3.2.1]octane-8-carbonyl)-butylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester