2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)-N-(pyridin-3-yl)benzamide

Base Information

Chemical Name:2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)-N-(pyridin-3-yl)benzamide
CAS No.:1362819-07-5
Molecular Formula:C₂₅H₂₅ClN₄O₃
Molecular Weight:464.952
Hs Code.:

Synonyms:2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)-N-(pyridin-3-yl)benzamide

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Chemical Property of 2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)-N-(pyridin-3-yl)benzamide

Chemical Property:

Purity/Quality:

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Technology Process of 2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)-N-(pyridin-3-yl)benzamide

There total 10 articles about 2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)-N-(pyridin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 462-08-8
pyridin-3-ylamine

: 1362821-41-7
2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)benzoic acid

: 1362819-07-5
2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)-N-(pyridin-3-yl)benzamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: 50-85-1
2-hydroxy-p-toluic acid

: 1362819-07-5
2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)-N-(pyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 10 steps

1: thionyl chloride / 24 h / 50 °C

2: N-chloro-succinimide / acetonitrile / 2 h / 100 °C

3: pyridine / 4 h

4: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

5: water; calcium carbonate / 1,4-dioxane / 6.33 h / 150 °C

6: caesium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

7: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 1 h / 0 °C

8: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 8 h / 20 °C

9: water; lithium hydroxide / tetrahydrofuran / 2 h / 40 °C

10: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

With pyridine; sodium chlorite; N-chloro-succinimide; N-Bromosuccinimide; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; caesium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 4670-56-8
methyl 2-hydroxy-4-methylbenzoate

: 1362819-07-5
2-(benzyloxy)-5-chloro-4-(4-methylpiperazine-1-carbonyl)-N-(pyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: N-chloro-succinimide / acetonitrile / 2 h / 100 °C

2: pyridine / 4 h

3: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

4: water; calcium carbonate / 1,4-dioxane / 6.33 h / 150 °C

5: caesium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

6: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 1 h / 0 °C

7: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 8 h / 20 °C

8: water; lithium hydroxide / tetrahydrofuran / 2 h / 40 °C

9: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

With pyridine; sodium chlorite; N-chloro-succinimide; N-Bromosuccinimide; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; caesium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;