1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

Base Information

Chemical Name:1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine
CAS No.:133272-17-0
Molecular Formula:C₂₂H₂₉N₂O₈P
Molecular Weight:480.455
Hs Code.:

Synonyms:1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

Suppliers and Price of 1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

There total 20 articles about 1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 133272-16-9
1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

: 133272-17-0
1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 70 ℃; for 1h;

Reference yield: 81.0%

: 213611-27-9
Benzoic acid (2S,3S,5R)-3-(diethoxy-thiophosphorylmethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

: 133272-17-0
1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(98)01335-5

Reference yield:

: 63366-59-6
P,P'-methanediyl-bis-phosphonothioic acid tetra-O-ethyl ester

: 133272-17-0
1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

Guidance literature:: Multi-step reaction with 7 steps

1: n-BuLi / tetrahydrofuran

2: p-TsOH / methanol

3: pyridine

4: NBS / CH₂Cl₂

5: n-Bu₃SnH/Et₃B / toluene / -50 °C

6: 1.) bis-trimethylsilylacetamide; 2.) TiCl₄ / 1.) CH₂Cl₂; 2.) CH₂Cl₂, 25 deg C, 1 h

7: 81 percent / m-CPBA / CH₂Cl₂ / Ambient temperature

With N-Bromosuccinimide; n-butyllithium; N,O-bis-(trimethylsilyl)-acetamide; triethyl borane; tri-n-butyl-tin hydride; titanium tetrachloride; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4039(98)01335-5