1-(5-O-benzoyl-2,3-dideoxy-3-phosphonomethyl-β-D-ribofuranosyl)thymine disodium salt

Base Information

Chemical Name:1-(5-O-benzoyl-2,3-dideoxy-3-phosphonomethyl-β-D-ribofuranosyl)thymine disodium salt
CAS No.:133272-19-2
Molecular Formula:C₁₈H₁₉N₂O₈P*2Na
Molecular Weight:468.311
Hs Code.:

Synonyms:1-(5-O-benzoyl-2,3-dideoxy-3-phosphonomethyl-β-D-ribofuranosyl)thymine disodium salt

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Chemical Property of 1-(5-O-benzoyl-2,3-dideoxy-3-phosphonomethyl-β-D-ribofuranosyl)thymine disodium salt

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Technology Process of 1-(5-O-benzoyl-2,3-dideoxy-3-phosphonomethyl-β-D-ribofuranosyl)thymine disodium salt

There total 6 articles about 1-(5-O-benzoyl-2,3-dideoxy-3-phosphonomethyl-β-D-ribofuranosyl)thymine disodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 133272-17-0
1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine

: 133272-19-2
1-(5-O-benzoyl-2,3-dideoxy-3-phosphonomethyl-β-D-ribofuranosyl)thymine disodium salt

Guidance literature:: With trimethylsilyl iodide; In chloroform; at 0 ℃; for 0.5h;

Reference yield:

: 31843-77-3
1,2-di-O-acetyl-5-O-benzoyl-3-deoxy-3-O-(diethoxyphosphonomethyl)-β-D-ribofuranose

: 133272-19-2
1-(5-O-benzoyl-2,3-dideoxy-3-phosphonomethyl-β-D-ribofuranosyl)thymine disodium salt

Guidance literature:: Multi-step reaction with 5 steps

1: 53 percent / 1.) hexamethyldisilazane (HDMS), chlorotrimethylsilane (CTS), pyridine, 2.) potassium perfluorobutanesulfonate (KPBS), CTS / 1.) reflux, 2.) MeCN, dichloroethane, reflux, 4 h

2: 63 percent / hydroxylammonium acetate, pyridine / 26 h / Ambient temperature

3: 92 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 5 h / Ambient temperature

4: 82 percent / tributyltin hydride, azobisisobutyronitrile (AIBN) / toluene / 1 h / 70 °C

5: 60 percent / iodotrimethylsilane / CHCl₃ / 0.5 h / 0 °C

With pyridine; dmap; chloro-trimethyl-silane; 2,2'-azobis(isobutyronitrile); trimethylsilyl iodide; tri-n-butyl-tin hydride; hydroxylamine acetate; potassium nonaflate; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; chloroform; toluene;

Reference yield:

: 133272-14-7
1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)thymine

: 133272-19-2
1-(5-O-benzoyl-2,3-dideoxy-3-phosphonomethyl-β-D-ribofuranosyl)thymine disodium salt

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 5 h / Ambient temperature

2: 82 percent / tributyltin hydride, azobisisobutyronitrile (AIBN) / toluene / 1 h / 70 °C

3: 60 percent / iodotrimethylsilane / CHCl₃ / 0.5 h / 0 °C

With dmap; 2,2'-azobis(isobutyronitrile); trimethylsilyl iodide; tri-n-butyl-tin hydride; In dichloromethane; chloroform; toluene;